Abstract： Objective： To observe the clinical effect of Qingyu Jiangzhuo Decoction combined with western medicine on decompensated period of renal insufficiency in chronic renal failure (CRF) of spleenkidney qi-deficiency type. Methods ： A total of 100 patients with decompensated period of renal insufficiency in CRF of spleen-kidney qi-deficiency type were selected and divided into the study group and the control group according to the random number table method，with 50 cases in each group. The control group was given routine western medicine and the study group was additionally treated with Qingyu Jiangzhuo Decoction based on the treatment of the control group. Both groups were treated for 2 months. The clinical effects， incidence of adverse reactions， and the symptom scores and levels of indexes of kidney function，including serum creatinine (SCr)，blood urea nitrogen (BUN) and creatinine clearance rate (CCr)， as well as the levels of serum C- reactive protein (CRP) were compared between the two groups before and after treatment. Results： After 2 months of treatment， the total clinical effective rate was 90.00% in the study group，higher than that of 74.00% in the control group (P＜0.05). After treatment，the scores of fatigue and lack of strength，intake less and poor appetite，sore and weak waists and short of breath and reluctant to speak in both groups were decreased when compared with those before treatment (P＜0.05)，and the above 4 scores in the study group were lower than those in the control group (P＜0.05). After treatment， the levels of SCr and BUN in both groups were decreased when compared with those before treatment (P＜0.05)，and the above 2 levels in the study group were lower than those in the control group (P＜0.05)； the CCr values in both groups were increased when compared with those before treatment (P＜0.05)，and the CCr value in the study group was higher than that in the control group (P＜ 0.05). After treatment，the serum CRP levels in both groups were decreased when compared with those before treatment (P＜0.05)，and the serum CRP level in the study group was lower than that in the control group (P＜0.05). During treatment，the incidence of adverse reactions was 8.00% in the study group，and 6.00% in the control group， there being no significance in the difference (P＞0.05). Conclusion： Qingyu Jiangzhuo Decoction combined with western medicine for decompensated period of renal insufficiency in CRF of spleen- kidney qi- deficiency type can enhance the clinical effect，mitigate the clinical symptoms， inhibit the inflammatory responses of the body，and improve the kidney function，with good safety.