Abstract： Objective： To observe the clinical effect of Xiaoyan Lidan Tablets assisting laparoscopic cholecystectomy on acute calculous cholecystitis and its effect on high- sensitive C- reactive protein (hs- CRP) and the level of procalcitonin (PCT). Methods： A total of 78 patients with acute calculous cholecystitis treated with laparoscopic cholecystectomy were analyzed retrospectively and divided into the control group and the observation group according to different treatment methods，with 39 cases in each group. The control group was given the laparoscopic cholecystectomy， and the observation group was additionally treated with oral administration of Xiaoyan Lidan Tablets based on the treatment of the control group. The clinical effects，improvement time of symptoms after surgery，incidence of adverse reactions as well as the traditional Chinese medicine (TCM) syndrome scores and levels of hs- CRP and PCT were compared between the two groups before and after treatment. Results： The total effective rate was 94.87% in the observation group，and 79.48% in the control group，the difference being significant (P＜ 0.05). The recovery time of bowel sound，first exhaust time，first defecation time and hospitalization time in the observation group were shorter than those in the control group，the difference being significant (P＜ 0.05). After treatment，the TCM syndrome scores of pain in upper abdomen，tenderness，bitter taste in the morning，nausea and vomiting，continuous low-grade fever，yellow skin and eyes，and red tongue and yellow coating in both groups were decreased when compared with those before treatment (P＜0.05)， and the above seven scores in the observation group were lower than those in the control group (P＜0.05). After treatment， the levels of hs- CRP and PCT in the observation group were lower than those in the control group and before treatment (P＜0.05)， and there was no significant difference being found in the comparisons of above two indexes in the control group before and after treatment (P＞0.05). The incidence of adverse reactions was 7.69% in the observation group，and 20.51% in the control group，there being no significance in the difference (P＞0.05). Conclusion： Xiaoyan Lidan Tablets combined with laparoscopic cholecystectomy for acute calculous cholecystitis can enhance the curative effect， shorten the recovery time of gastrointestinal function，and decrease the levels of hs-CRP and PCT，with better safety.