Abstract：Objective：To observe the clinical effect of Tripterygium Glycosides Tablets combined with Diclofenac Sodium Sustained- Release Tablets for rheumatoid arthritis. Methods： A total of 68 cases of rheumatoid arthritis were divided into the control group and the treatment group according to the random number table method，with 34 cases in each group. The control group was given the oral administration of Diclofenac Sodium Sustained- Release Tablets， and the treatment group was additionally treated with Tripterygium Glycosides Tablets based on the treatment of the control group. The improvement of symptoms and signs，and the changes in levels of serological indexes including C-reactive protein (CRP)， anti- cyclic citrullinated peptide antibody (ACCP)，rheumatoid factors (RF)，and anti- streptolysin O (ASO) were compared between the two groups before and after treatment. Clinical effects and the incidence of adverse reactions were counted. Results：The total effective rate was 97.06% in the treatment group and 79.41% in the control group， the difference being significant between the two groups (P＜0.05). After treatment， the number of swollen joints， the number of tenderness joints， the duration of morning stiffness，and Visual Analogue Scale (VAS) scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above indexes of symptoms and signs in the treatment group were lower than those in the control group (P＜0.05). After treatment，the levels of RF，ASO，CRP，and ACCP in serum in the two groups were decreased when compared with those before treatment，and the above indexes in the treatment group were lower than those in the control group (P＜0.05). During treatment，the incidence of adverse reactions was 5.88% in the treatment group and 11.76% in the control group， there being no significance in the difference between the two groups (P＞0.05). Conclusion： Tripterygium Glycosides Tablets combined with Diclofenac Sodium Sustained- Release Tablets has a significant curative effect in the treatment of rheumatoid arthritis， and can improve clinical symptoms， signs，and joint function，relieve pain，and down-regulate the levels of inflammatory factors and RF，with fewer adverse reactions.