Abstract：Objective：To observe the clinical effect of modified Yuebi and Banxia Decoction combined with comprehensive western medicine therapy on bronchial asthma with heat- wheezing syndrome. Methods：A total of 200 patients with asthma were selected and divided into the observation group and the control group according to the random number table method， with 100 cases in each group. The control group was given comprehensive western medicine therapy， and the observation group was additionally treated with modified Yuebi and Banxia Decoction based on the treatment of the control group. The two groups were treated for 2 months. The clinical effects in both groups were evaluated； the traditional Chinese medicine (TCM) syndrome scores， lung function， scores of Airways Questionnaire 20- rised (AQ20R) and Asthma Control Questionnaire- 5 (ACQ- 5)， airway hyperresponsiveness， and levels of intercellular adhesion molecule-1 (ICAM-1) and eosinophils (EOS) were compared between the two groups and the drug safety was also evaluated. Results： The total effective rate was 97.00% in the observation group， higher than that of 87.00% in the control group (P＜0.05). After treatment， all TCM syndrome scores in both groups were decreased when compared with those before treatment， and all TCM syndrome scores in the observation group were lower than those in the control group (P＜0.05). After treatment，the forced expiratory volume in one second as a percentage of expected value (FEV1%)，and ratio of forced expiratory volume in one second and forced vital capacity (FEV1/FVC) in the two groups were increased when compared with those before treatment， and the scores of AQ20- R and ACQ- 5 were decreased when compared with those before treatment (P＜0.05)； the FEV1% and FEV1/FVC in the observation group were higher than those in the control group， and the scores of AQ20- R and ACQ- 5 were lower than those in the control group (P＜0.05). After treatment， the minimum cumulative dose required for a 20% decrease in FEV1 (PD20- FEV1) in both groups was higher than that before treatment， and the increases in FEV1 and FEV1 of absolute value in bronchial dilation test and the peak expiratory flow rate (PEFR) were lower than those before treatment (P＜0.05)； the PD20- FEV1 in the observation group was higher than that in the control group，and the increases in FEV1 and FEV1 of absolute value in bronchial dilation test and the PEFR were lower than those in the control group (P＜0.05). After treatment，the levels of ICAM-1 and EOS in both groups were lower than those before treatment (P＜0.05)，and the above two levels in the observation group were lower than those in the control group (P＜0.05). There was no significant difference being found in the comparison of incidence of adverse reactions between the two groups (P＞0.05). Conclusion： Modified Yuebi and Banxia Decoction combined with comprehensive western medicine therapy has a definite clinical effect on bronchial asthma with heat-wheezing syndrome， which can improve the airway hyperresponsiveness，inhibit the chronic inflammatory responses of airway， and enhance the lung function and curative effect with good safety.