Abstract： Objective： To observe the clinical effect of Jiejing Zhitong Prescription combined with external application of Gang'an Ointment for chronic anal cleft (CAF). Methods：A total of 156 cases of CAF patients were selected as the study subjects and divided into two groups according to the random number table method，with 78 cases in each group. Based on the treatment of Nitroglycerin Ointment，the control group was additionally given external application of Gang'an Ointment，and the Trial group was additionally treated with Jiejing Zhitong Prescription based on the treatment of the control group. The traditional Chinese medicine (TCM) syndrome scores， IAS basal pressure(IASP)， Visual Analogue Scale (VAS) scores， Wexner Continence Grading Scale scores，and World Health Organization Quality of Life (WHOQOL) scores before and after treatment as well as the curative effects of TCM therapy were compared between the two groups. Results：The total effective rate of TCM therapy was 97.44% in the trial group，higher than that of 88.46% in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparison of TCM syndrome scores between the two groups (P＞0.05)； after treatment， TCM syndrome scores in the two groups were decreased (P＜0.05)，and the scores in the trial group were lower than those in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparison of IASP and the scores of VAS and Wexner between the two groups (P＞0.05)； after treatment，IASP and the scores of VAS and Wexner in the two groups were decreased (P＜0.05)，and the above indexes in the trial group were lower than those in the control group (P＜0.05). Before treatment， there was no significant difference being found in the comparison of single score and the total scores in WHOQOL between the two groups (P＞0.05)；after treatment，each single score and the total scores in WHOQOL in the two groups were increased (P＜0.05)，and the scores in the trial group were higher than those in the control group (P＜0.05). Conclusion： Jiejing Zhitong Prescription combined with external application of Gang'an Ointment has a significant effect in treating CAF，which can effectively relieve TCM syndromes，recover clinical indexes，and improve the degree of pain，anal function and quality of life.