Abstract： Objective： To observe the clinical effect of Buqi Tiaoqi Powder combined with pelvic floor rehabilitation for pelvic organ prolapse. Methods：A total of 80 cases of patients with pelvic organ prolapse were divided into the observation group and the control group according to the random number table method， with 40 cases in each group. The control group was routinely treated with electrical stimulation and biofeedback by pelvic floor rehabilitation instrument，and the observation group was additionally treated with Buqi Tiaoqi Powder based on the treatment of the control group. The symptom scores of qi deficiency， the pelvic floor muscle surface electromyography value，the severity of urinary incontinence，sex function and the grading of Pelvic Organ Prolapse Quantification (POP-Q grading) were compared between the two groups before and after treatment. Results：After treatment，the symptom scores of qi deficiency in the two groups were decreased when compared with those before treatment (P＜0.05)， and the symptom score of qi deficiency in the observation group was lower than that in the control group (P＜0.05). After treatment， the pelvic floor muscle surface electromyography values in fast- twitch stage， tension contraction stage，and endurance contraction stage in the two groups were increased when compared with those before treatment (P＜0.05)， and the pelvic floor muscle surface electromyography values in fasttwitch stage，tension contraction stage，and endurance contraction stage in the observation group were higher than those in the control group (P＜0.05). After treatment，the scores of International Consultation on Incontinence Questionnaire- Short Form (ICIQ- SF) in the two groups were decreased when compared with those before treatment，and the scores of Female Sexual Function Index (FSFI) were increased when compared with those before treatment (P＜0.05)；the ICIQ- SF score in the observation group was lower than that in the control group， and FSFI score was higher than that in the control group (P＜0.05). After treatment，the POP-Q grading in the two groups was better than that before treatment (P＜0.05)，and the POP- Q grading in the observation group was better than that in the control group (P＜0.05). Conclusion： Buqi Tiaoqi Powder combined with pelvic floor rehabilitation can effectively improve pelvic floor muscle strength，symptoms and quality of life.