Abstract：Objective：To observe the clinical effect of Pudilan Xiaoyan Oral Liquid in adjuvant treatment of children with herpetic angina. Methods： A total of 200 cases of children with herpetic angina were divided into the control group and the treatment group according to the random number table method，with 100 cases in each group. The control group was given routine symptomatic treatment，and the treatment group was additionally given Pudilan Xiaoyan Oral Liquid for adjuvant treatment based on the treatment of the control group. Traditional Chinese medicine (TCM) syndrome scores， immune function indexes， and inflammatory factors were compared before and after treatment between the two groups. The clinical effects，the remission time of symptoms and the incidence of adverse reactions were compared between the two groups. Results： After treatment， the total effective rate was 96.00% in the treatment group， higher than that of 88.00% in the control group (P＜0.05). The antipyretic time， the regression time of herpes and ulcer，and the disappearance time of salivation in the treatment group were shorter than those in the control group (P＜0.05). After treatment， TCM syndrome scores and the levels of tumor necrosis factor- α (TNF- α)， interleukin- 6 (IL- 6)， and interleukin- 10 (IL- 10) in the two groups were lower than those before treatment (P＜0.05)，and the TCM syndrome score and the levels of inflammatory factors in the treatment group were lower than those in the control group (P＜0.05). After treatment， the levels of immunoglobulin (Ig) A， IgG， and IgM in the two groups were higher than those before treatment (P＜ 0.05)，and the above indexes in the treatment group were higher than those in the control group (P＜0.05). There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups (P＞0.05). Conclusion：Pudilan Xiaoyan Oral Liquid has a definite curative effect in adjuvant treatment of children with herpetic angina， which can improve the body immunity of children， promote the improvement of clinical symptoms and reduce the inflammatory response of body，with high safety.