Abstract： Objective： To observe the clinical effect of Gengnian Pingmai Decoction combined with Valsartan for hypertension of disharmony of the chong and ren mai type in perimenopausal period. Methods：A total of 120 cases of patients with hypertension of disharmony of the chong and ren mai type in perimenopausal period were selected and divided into the observation group and the control group according to the random number table method， with 60 cases in each group. Two cases in the control group and one case in the observation group were excluded. Finally，58 cases in the control group and 59 cases in the observation group were included. The observation group was treated with Gengnian Pingmai Decoction combined with Valsartan，and the control group was simply treated with Valsartan. Both groups were treated for 12 weeks. The clinical effects in the two groups were evaluated. Before and after treatment， the traditional Chinese medicine (TCM) syndrome scores， the levels of follicle stimulating hormone (FSH)， luteinizing hormone (LH)， estrogen (E2)， total cholesterol (TC)， low density lipoprotein (LDL)， and triglyceride (TG)， 24- hour mean systolic blood pressure (24 hSBP)， 24- hour mean diastolic blood pressure (24 hDBP)， 24- hour systolic blood pressure coefficient of variation (24 hSBPcv)， and 24- hour diastolic blood pressure coefficient of variation (24 hDBPcv) were compared between the two groups. Results： After treatment， the total clinical effective rate was 91.53% in the observation group， higher than that of 67.24% in the control group (P＜0.05). After treatment，TCM syndrome scores in the two groups were decreased when compared with those before treatment (P＜0.05)， and the TCM syndrome score in the observation group was lower than that in the control group (P＜0.05). After treatment， 24 hSBP， 24 hDBP and 24 hSBPcv in the two groups were decreased when compared with those before treatment (P＜0.05)， the 24 hDBPcv in the observation group was lower than that before treatment (P＜0.05)，and there was no significant difference being found in the comparison of 24 hDBPcv in the control group before and after treatment (P＞0.05)；24 hSBP，24 hDBP，24 hSBPcv，24 hDBPcv in the observation group were lower than those in the control group (P＜0.05). After treatment，the levels of FSH and LH in serum in the observation group were decreased when compared with those before treatment，and were lower than those in the control group (P＜0.05)；E2 level in serum in the observation group was increased when compared with that before treatment，and was higher than that in the control group (P＜0.05). Before and after treatment， there was no significant difference being found in the comparison of levels of FSH，LH and E2 in serum in the control group (P＞0.05). After treatment，TG levels in the two groups were decreased when compared with those before treatment (P＜0.05)，and TG level in the observation group was lower than that in the control group (P＜0.05)；the levels of TC and LDL in the observation group were decreased when compared with those before treatment and were lower than those in the control group (P＜0.05). There was no significant difference being found in the comparison of levels of TC and LDL in the control group before and after treatment (P＞0.05). Conclusion： On the basis of Valsartan，the treatment of Gengnian Pingmai Decoction can reduce the average blood pressure of patients with hypertension of disharmony of the chong and ren mai type in perimenopausal period， relieve perimenopausal symptoms，and regulate the levels of estrogen and lipid metabolism.