Abstract： Objective： To analyze and discuss the medication rules of famous physicians in the Qing Dynasty to treat swelling disease. Methods： Swellling- related medical cases recorded in Qingdai Mingyi Yi'an Jinghua (Essential Case Records of Famous Physicians of the Qing Dynasty) were collected and sorted out. Prescription database was established via Microsoft Excel 2020， and the prescription data were standardized according to relevant standards. With the help of Chinese Medicine Inheritance Assistance Platform System (V2.5)，the medicine frequency，natures and flavors，channel entry，effect distribution， association rules and complex entropy clustering were analyzed. Results：The medical cases of 15 famous physicians for the treatment of swelling were included，involving a total of 100 prescriptions，including 208 kinds of Chinese herbs，and the total frequency of medication was 1 042 times. There were 25 kinds of highfrequency Chinese herbs (occurrence frequency≥10 times)，and Poria was the most frequently used herbs (77 times). The natures of herbs were mainly warm，cold and balanced，and the five flavors were mostly sweet， acrid and bitter； most of the herbs used entered into the spleen， lung， stomach and kidney meridians. The largest distribution of herbal effects was the herbs for deficiency-supplementing. The most commonly used drug-pair was Citri Reticulatae Pericarpium-Poria. The most commonly used three-kinds herbal combination was "Citri Reticulatae Pericarpium- Poria- Arecae Pericarpium". The high confidence association rules included "Alismatis Rhizoma→ Poria". Entropy hierarchical cluster analysis obtained 10 core herbal combinations and 5 potential new prescriptions. Conclusion：The treatment of swelling disease by famous physicians in the Qing Dynasty mainly focuses on promoting urination and percolating dampness， and also on supplementing deficiency and moving qi. At the same time，they also used methods of relieving cough and panting， diffusing the lung and dissipating cold， warming yang and removing dampness， dissolving phlegm and moving qi according to the specific situation.