Literature Study on the Distribution of Traditional Chinese Medicine Syndromes and the Medication Rules of Chinese Medicine in Children with Chronic Cough
Objective: To summarize the distribution characteristics of traditional Chinese medicine (TCM) syndromes of chronic cough in children and the rules of prescription of Chinese medicine based on data mining technology. Methods:To search the clinical observation or clinical randomized controlled study of TCM in treating chronic cough in children included in CNKI,Wanfang,VIP,and the Chinese Biomedical Literature Database from 2006 to 2022, SPSS26.0 was used to carry out frequency statistics and drug cluster analysis on the syndrome types, syndrome elements, and Chinese medicine included in the literature, and R4.2.1 apriori function was used to carry out visual analysis of association rules. The core complex network of Chinese medicine was established Cytoscape 3.9.1. Results: A total of 122 articles were included, involving 6 328 patients, covering 45 types of TCM syndromes. The first four types of syndromes with frequency were lung and spleen qi deficiency,phlegm-damp invading the lung,phlegmheat blocking the lung,and wind-heat invading the lung. A total of 14 disease-related syndrome elements and 5 disease- position syndrome elements were extracted, of which the first six were phlegm, heat, external wind,qi deficiency,dampness and yin deficiency, and the first two types of disease location syndrome elements were lung and spleen. A total of 150 prescriptions were used, involving 163 drugs. The first six drugs with higher frequency of use were Glycyrrhizae Radix et Rhizoma,Armeniacae Semen Amarum, Pinelliae Rhizoma Praeparatum, Poria, Citri Reticulatae Pericarpium and Platycodonis Radix. Commonly used drug pairs include Poria- Citri Reticulatae Pericarpium, Citri Reticulatae Pericarpium- Pinelliae Rhizoma Praeparatum,etc. The drug groups include Pinelliae Rhizoma Praeparatum-Glycyrrhizae Radix et Rhizome-Citri Reticulatae Pericarpium , Poria-Glycyrrhizae Radix et Rhizome-Citri Reticulatae Pericarpium,etc. The results of cluster analysis showed that 32 high-frequency Chinese medicines could be grouped into 9 categories. Conclusion:Children's chronic cough should be divided into deficiency and excess,and the disease location is mainly in the lung and spleen. Deficiency syndrome elements are often qi deficiency and yin deficiency,while excess syndrome elements are mainly phlegm,heat and dampness. The basic treatment is to strengthen the spleen and benefit the lung, expel wind and clear heat, and dissipate phlegm and stop cough,and make modification according to symptoms.