Abstract: Objective: To observe the clinical effect of Jianpi Wenshen Decoction combined with western medicine for subclinical hypothyroidism and its effect on thyroid function,lipid metabolism,and heart function. Methods:A total of 110 cases of patients with subclinical hypothyroidism were selected as research objects and divided into the control group and the study group according to the random number table method, with 50 cases in each group. The control group was treated with Levothyroxine Sodium Tablets, and the study group was additionally treated with Jianpi Wenshen Decoction based on the treatment of the control group. The levels of free tetraiodothyronine (FT4), free triiodothyronine (FT3), thyroid stimulating hormone (TSH),high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL- C), total cholesterol (TC), and triacylglycerol (TG) in serum, left ventricular ejection after treatment between the two groups; the clinical effects were compared between the two groups. Results:The total effective rate of treatment was 96.36% in the study group,higher than that of 81.82% in the control group (P<0.05). Before treatment, there was no significant difference being found in the comparison of the levels of FT3, FT4, and TSH in serum between the two groups (P>0.05). After treatment,the levels of FT3 and FT4 in serum in the two groups were increased (P<0.05),and the above levels in the study group were higher than those in the control group (P<0.05); the TSH levels in serum in the two groups were decreased (P<0.05),and the TSH level in the study group was lower than that in the control group (P<0.05). Before treatment, there were no significant difference being found in the comparison of the levels of TC,TG,LDL- C, and HDL- C in serum between the two groups (P>0.05). After treatment, the levels of TC, TG, and LDL- C in serum in two groups were decreased (P<0.05), and the above levels in the study group were lower than those in the control group (P<0.05); the levels of HDL-C in serum in the two groups were increased (P<0.05),and the HDL-C level in the study group was higher than that in the control group (P<0.05). Before treatment,there was no significant difference being found in the comparison of LVEF,and blood flow velocity at peak A and peak E between the two groups (P>0.05). After treatment,blood flow velocity at peak A in the two groups was decreased (P<0.05),and blood flow velocity at peak A in the study group was lower than that in the control group (P<0.05); the blood flow velocity at peak E,and the LVEF in the two groups were increased (P<0.05),and blood flow velocity at peak E, and LVEF in the study group were higher than those in the control group (P<0.05). Conclusion: Jianpi Wenshen Decoction combined with western medicine for subclinical hypothyroidism can improve thyroid function and heart function,regulate the levels of lipid metabolism,and enhance the clinical effect.