Abstract：Objective：To observe the clinical effect of Daming Decoction for diabetic retinopathy with dual deficiency of qi and yin syndrome and static blood obstructing the collaterals syndrome. Methods：A total of 80 cases of patients with diabetic retinopathy with dual deficiency of qi and yin syndrome and static blood obstructing the collaterals syndrome were divided into two groups， with 35 cases in the western medicine group and 45 cases in the Chinese medicine group. The western medicine group was treated with Calcium Dobesilate Capsules，and the Chinese medicine group was treated with Daming Decoction. Visual acuity indexes and traditional Chinese medicine (TCM) syndrome scores were compared before and after treatment between the two groups， and the curative effect of TCM syndromes and clinical effects were compared between the two groups. Results：Before treatment，there was no significant difference being found in the comparison of visual acuity between the two groups (P＞0.05). After treatment， the visual acuity in the two groups were increased (P＜0.05)，and the visual acuity in the Chinese medicine group was higher than that in the western medicine group (P＜0.05). Before treatment， there was no significant difference being found in the comparison of TCM syndrome scores between the two groups (P＞0.05). After treatment，TCM syndrome score in the Chinese medicine group was decreased (P＜0.05)，and was lower than that in the western medicine group (P＜0.05). The total curative effective rate of TCM syndrome was 84.44% in the Chinese medicine group， higher than that of 28.57% in the western medicine group (P＜ 0.05). The total clinical effective rate was 83.13% in the Chinese medicine group， higher than that of 53.13% in the western medicine group (P＜0.05). During the treatment，there was no significant change in vital signs such as heart rate， body temperature， respiration and pulse， coagulation function， blood routine， urine routine， and liver and kidney function in the two groups， and no serious adverse event occurred in the two groups. Conclusion：Daming Decoction for diabetic retinopathy with dual deficiency of qi and yin syndrome and static blood obstructing the collaterals syndrome can improve visual acuity，reduce TCM syndrome scores，and increase the total clinical effective rate without serious adverse events.