Abstract： Objective： To observe the clinical effect of modified Shenqi Dihuang Decoction combined with Roxadustat for renal anemia in non- dialysis chronic kidney disease with spleen- kidney qi deficiency syndrome. Methods： A total of 94 cases of patients with renal anemia in non- dialysis chronic kidney disease with spleen-kidney qi deficiency syndrome were divided into the control group and the observation group according to the random number table method，with 47 cases in each group. The control group was treated with Roxadustat，and the observation group was additionally treated with modified Shenqi Dihuang Decoction based on the treatment of the control group. Both groups were treated for 8 weeks. Levels of hemoglobin， red blood cell count， and indexes of iron metabolism before and after treatment， clinical effects，and the incidence of adverse reactions were compared between the two groups. Results：After treatment， the total clinical effective rate was 95.74% in the observation group， higher than that of 82.98% in the control group (P＜0.05). Levels of hemoglobin and red blood cell count in the two groups were increased when compared with those before treatment (P＜0.05)， and the above 2 levels in the observation group were higher than those in the control group (P＜0.05). The levels of serum ferritin，iron ions，and transferrin in the two groups were increased when compared with those before treatment (P＜ 0.05)， and the 3 levels in the observation group were higher than those in the control group (P＜0.05). During treatment，the incidence of adverse reactions was 6.38% in the observation group and 10.64% in the control group， there being no significant difference being found in the comparison between the two groups (P＞0.05). Conclusion： Compared with the simple use of Roxadustat alone， the additional application with modified Shenqi Dihuang Decoction can enhance the curative effect in the treatment of renal anemia in non- dialysis chronic kidney disease with spleen- kidney qi deficiency syndrome，and can improve the anemia status of patients and correct the abnormal iron metabolism，with good safety.