Abstract：Objective：To observe the effect of Getong Tongluo Capsules combined with acupuncture on levels of neurological function and oxidative stress in patients with acute ischemic stroke (AIS). Methods：A total of 100 cases of AIS patients were divided into the control group，the Getong group，the acupuncture group ， and the combination group according to the random number table method ， with 25 cases in each group. The control group was given general treatment and specialized treatment； the Getong group was additionally given Getong Tongluo Capsules based on the treatment of the control group； the acupuncture group was additionally treated with acupuncture based on the treatment of the control group； the combination group was additionally treated with Getong Tongluo Capsules combined with acupuncture based on the treatment of the control group. All the 4 groups were treated for 14 days continuously. National Institutes of Health Stroke Scale (NIHSS) scores，levels of neurological impairment indexes [S-100B protein，neuron-specific enolase (NSE)，and glial fibrillary acidic protein (GFAP)]，and oxidative stress indexes [glutathione peroxidase (GSH-Px)，superoxide dismutase (SOD)，8-hydroxydeoxyguanosine (8-OHDG)，and malondialdehyde (MDA)] in the 4 groups were compared before and after treatment. Results： After treatment， NIHSS scores in the 4 groups were decreased when compared with those before treatment (P＜0.05)； NIHSS scores in the Getong group， the acupuncture group， and the combination group were lower than that in the control group (P＜0.05)，and NIHSS score in the combination group were lower than those in the Getong group and the acupuncture group (P＜0.05). After treatment，the levels of S- 100B protein，NSE，and GFAP in serum in the 4 groups were decreased when compared with those before treatment (P＜0.05)；the levels of S-100B protein，NSE，and GFAP in serum in the Getong group， the acupuncture group，and the combination group were lower than those in the control group (P＜0.05)， and the levels of S- 100B protein， NSE， and GFAP in serum in the combination group were lower than those in the Getong group and the acupuncture group (P＜0.05). After treatment， the levels of SOD and GSH-Px in serum in the 4 groups were increased when compared with those before treatment (P＜0.05)， and the levels of MDA and 8- OHDG in serum were decreased when compared with those before treatment (P＜0.05)； the levels of SOD and GSH- Px in serum in the Getong group， the acupuncture group，and the combination group were higher than those in the control group (P＜0.05)，and the levels of MDA and 8-OHDG in serum were lower than those in the control group (P＜0.05)；the levels of SOD and GSH-Px in serum in the combination group were higher than those in the Getong group and the acupuncture group (P＜0.05)；the levels of MDA and 8-OHDG in serum in the combination group were lower than those in the Getong group and the acupuncture group (P＜0.05). Conclusion：Getong Tongluo Capsules combined with acupuncture for AIS patients can effectively improve the degree of neurological deficit and oxidative stress indexes.