Abstract：Objective：To observe the distribution rule of traditional Chinese medicine (TCM) constitution distribution in patients with chronic lymphocytic thyroiditis (CLT) and its relationship with thyroid nodules. Methods：A total of 233 CLT physical examination patients were included and performed TCM constitution identification and thyroid ultrasonography. The TCM constitution distribution and its relationship with thyroid nodules were investigated. Results： The highest proportion of single constitution was qi deficiency constitution (83.69%)，blood stasis constitution (78.54%)，qi constraint constitution (58.80%)，damp-heat constitution (42.92%)，phlegm- damp (30.90%) and yin deficiency constitution (30.90%). Patients with qi deficiency constitution， blood stasis constitution， qi constraint constitution and inherited special constitution were significantly older than those without corresponding constitution (P＜0.05)，and patients with yin deficiency constitution were younger than those without yin deficiency constitution (P＜0.05). In patients with two constitutions， there were more with qi deficiency and blood stasis constitution (71.67% )， qi deficiency and phlegm- damp constitution (63.95% )， phlegm- damp and blood stasis constitution (58.80%)，qi deficiency and qi constraint constitution (52.79%)，qi constraint and blood stasis constitution (47.64% ) and qi constraint and phlegm- damp constitution (47.21% )， who were significantly older than those without corresponding constitution (P＜0.05)，and patients with qi deficiency and phlegmdamp constitution were significantly younger than those without that constitution (P＜0.05). In patients with three constitutions， there were more with constitution of qi deficiency， phlegm- damp and blood stasis (44.64% )， constitution of qi deficiency， qi constraint and blood stasis (39.06% )， constitution of qi constraint，phlegm-damp and blood stasis (38.63%)，and constitution of qi deficiency，qi constraint and phlegm- damp (38.20% ). In patients with four constitutions， there were more with constitution of qi deficiency，blood stasis，phlegm-damp and qi constraint (34.76%)，and they were significantly older than those without that constitution (P＜0.05). The majority of constitution type was four constitutions (51.93%). Patients with three，four and five constitutions were significantly older than those with single constitution and two constitutions (P＜0.05)，and they had a higher proportion of multiple thyroid nodules than that in patients with single constitution (P＜0.05). Patients with four and five constitutions were significantly older than those with three constitutions，and they had a higher proportion of multiple thyroid nodules than that in patients with two constitutions and three constitutions (P＜0.05). Conclusion： CLT patients are mainly characterized by biased constitution and mixed constitution. The older the age， the more complex the constitution， the more mixed constitution， and the higher the proportion of multiple thyroid nodules. It suggests that the clinical diagnosis and treatment of the disease should be taken into account the multiple constitution factors，and should avoid over-simple syndrome differentiation，so as to improve the clinical effect.