Abstract：Objective：To observe the effect of Shugan Yishen Qiwei Decoction combined with Tadalafil Tablets on patients with erectile dysfunction (ED) caused by antidepressants of selective serotonin reuptake inhibitors (SSRIs) type. Methods： A total of 112 cases of patients with ED caused by SSRIs antidepressants of liver depression and kidney deficiency type were selected and divided into two groups according to the random number table method， with 56 cases in each group. The control group was treated with Tadalafil Tablets， and the observation group was treated with Shugan Yishen Qiwei Decoction combined with Tadalafil Tablets. Both groups were treated for eight weeks. The clinical effects were compared between the two groups. Before and after treatment， traditional Chinese medicine syndrome scores， erectile function [Erection Hardness Scores (EHS)， International Index of Erectile Function- 5 (IIEF- 5) scores] ， psychological state [Patient Health Questionnaire- 9 (PHQ- 9) scores] ， vascular endothelial function [endothelin-1 (ET-1) and nitric oxide (NO) in serum，flow-mediated dilatation (FMD)] were evaluated. During the treatment， adverse reactions were observed. Results： After treatment，the curative effect in the observation group was better than that in the control group (P＜0.05). The scores of libido decrease，penile impotence，penile erection but not hard，grief and sentimentality， and dribbling urination，as well as PHQ-9 scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above six scores in the observation group were lower than those in the control group (P＜0.05). The scores of EHS and IIEF- 5 in the two groups were increased when compared with those before treatment (P＜0.05)， and the scores of EHS and IIEF- 5 in the observation group were higher than those in the control group (P＜0.05). The levels of ET- 1 in the two groups were decreased when compared with those before treatment，and the levels of NO and the values of FMD were increased when compared with those before treatment，differences being significant (P＜0.05). The level of ET-1 in the observation group was lower than that in the control group，and the level of NO and the value of FMD were higher than those in the control group， differences being significant (P＜0.05). No obvious adverse reaction occurred in the two groups. Conclusion：Shugan Yishen Qiwei Decoction combined with Tadalafil Tablets for ED caused by SSRIs antidepressants of liver depression and kidney deficiency type has an obvious effect， which can improve psychological state， vascular endothelial function， and erectile function of patients，with high safety.