Abstract： Objective： To observe the effect of electroacupuncture at scalp and body points on neurological function and inflammatory factors in patients with acute cerebral infarction (ACI) within 48 hours of onset. Methods： A total of 60 cases of patients with ACI within 48 hours of onset were selected and randomly divided into the control group and the electroacupuncture group， with 30 cases in each group. Both groups were treated with routine medical treatment；the control group was additionally treated with standard rehabilitation treatment， and the electroacupuncture group was additionally treated with electroacupuncture at scalp and body points； both groups were treated for 14 days. Before and after treatment，clinical effects were compared between the two groups，and the changes in neural function， tumor necrosis factorα (TNF- α)， interleukin- 10 (IL- 10)， and interleukin- 17 (IL- 17) in serum were observed； the correlation was compared. The scores of the National Institutes of Health Stroke Scale (NIHSS) and Barthel Index of Activities of Daily Living (Barthel) were compared between the two groups before and after treatment and three months after the end of the treatment，and the short-term and longterm effects of treatment were observed. Results：After treatment，the scores of NIHSS and Barthel and the levels of TNF-α，IL-10，and IL-17 in serum in the two groups were improved (P＜0.05)；the NIHSS scores and the levels of TNF-α and IL-17 in serum in the electroacupuncture group were lower than those in the control group，and Barthel scores and IL- 10 in serum in the electroacupuncture group were higher than those in the control group (P＜0.05). There was a positive correlation between NIHSS scores and TNF- α and IL- 17 in serum， and a negative correlation between NIHSS scores and IL- 10 (P＜0.05). The total clinical effective rate in the electroacupuncture group was higher than that in the control group (P＜0.05). There was a improvement in NIHSS scores and Barthel indexes between the two groups three months after the end of the treatment (P＜0.05). Conclusion： Conventional medication combined with rehabilitation therapy can significantly improve the neurological deficit in patients with ACI， enhance their daily living ability， and promote the recovery of limb motor function. On this basis， electroacupuncture at the scalp and body points within 48 hours after the onset of ACI can enhance the above curative effects and have a good long- term effect. The mechanism of action may be related to the regulation of the expression of inflammatory factors such as TNF- α， IL- 10， and IL- 17， and the decrease in inflammatory damage in brain tissue.