Abstract： Objective： To observe the effect of the therapy of application of thumb- tack needling for subcutaneous embedding combined with functional on-bed exercise on early rehabilitation of degenerative lumbar spinal stenosis (DLSS) after percutaneous endoscopic lumbar discectomy (PELD). Methods：A total of 68 DLSS patients receiving PELD were randomly divided into the treatment group and the control group， with 34 cases in each group. The control group was given routine treatment and functional on-bed exercise after surgery，and the treatment group was additionally treated with thumb-tack needling for subcutaneous embedding. The perioperative indexes in the two groups were compared. Before and after treatment，the scores of Visual Analogue Scale (VAS)，Japanese Orthopaedic Association (JOA)，Oswestry Dability Index (ODI)， surface electromyographic signals of lumbosacral multifidus muscles， including average electromyography (AEMG)，median frequency (MF) and mean power frequency (MPF) and levels of serum inflammatory factors，including tumor necrosis factor- α (TNF- α)，interleukin- 6 (IL- 6)，and nitric oxide (NO) as well as the rehabilitation nursing compliance were compared in the two groups. Results： There were no significant differences in the comparison of surgery duration，intraoperative blood loss and mean postoperative hospital stay between the two groups (P＞0.05). After treatment，the VAS and ODI scores in the two groups were decreased when compared with those before treatment (P＜0.05)， and the JOA scores were increased when compared with those before treatment； the VAS and ODI scores in the treatment group were lower than those in the control group (P＜0.05)，and the JOA score in the treatment group was higher than that in the control group (P＜0.05). After treatment，the levels of AEMG，MPF and MF in the two groups were increased when compared with those before treatment (P＜0.05)， and the above levels in the treatment group were higher than those in the control group (P＜0.05). After treatment， the serum levels of TNF- α，IL- 6 and NO in the two groups were decreased when compared with those before treatment (P＜0.05)， and the above levels in the treatment group were lower than those in the control group (P＜0.05). After treatment，the nursing compliance rate in the treatment group was 97.06%， higher than that of 76.47% in the control group，the difference being significant (P＜0.05). Conclusion：The therapy of application of thumb- tack needling for subcutaneous embedding combined with functional onbed exercise helps to relieve lumbago of DLSS patients receiving PELD，promote the recovery of lumbar function， reduce the levels of inflammatory factors， effectively improve the function of lumbosacral multifidus muscles and enhance their quality of life and nursing compliance.