Abstract：By sorting out the origin and flow of sweat syndrome，this article clarifies the origin of night sweat，and summarizes and reviews the pathogenesis of night sweat by Chinese medicine practitioners of all dynasties. It is clear that the pathogenesis of night sweat involves yin deficiency，blood deficiency，yang deficiency， yin- yang deficiency and other deficiency syndromes， as well as the excess syndromes like dampness，heat and stasis. It is pointed out that the idea that “spontaneous sweating is ascribed to yang deficiency，and night sweat is ascribed to yin deficiency" has disadvantages of the times. The paper further discusses the clinical thinking of treating night sweat from six- channel syndrome differentiation ， and discusses the pathogenesis chain of "six channels-nutritious qi and defensive qi-sweat pore ”， the relationship between the six channels and nutritious qi and defensive qi， and the treatment overview of night sweat from six- channel syndrome differentiation. It is believed that it is difficult to completely treat night sweat from the conventional treatment thoughts of eight-principle syndrome differentiation，zang-fu syndrome differentiation and syndrome differentiation based on etiology. However ， if six- channel syndrome differentiation is adopted，it can integrate the eight principles with zang-fu and control nutritious qi， defensive qi， qi and blood， which is a multidimensional and three- dimensional treatment idea， suitable for the diagnosis and treatment of night sweat，a common disease associated with miscellaneous diseases in internal medicine.