Abstract： Objective： To observe the clinical effect of San'ao Tablets combined with routine western medicine for acute exacerbation of chronic bronchitis in senile patients. Methods： A total of 94 cases of senile patients with acute exacerbation of chronic bronchitis were selected and divided into the observation group and the control group according to the random number table method，with 47 cases in each group. The control group was treated with routine western medicine，and the observation group was additionally treated with San'ao Tablets based on the treatment of the control group. The clinical effects in the two groups were evaluated. Before and after treatment， the traditional Chinese medicine syndrome scores， the lung function indexes，and the levels of inflammatory factors were compared between the two groups. The occurrence of adverse reactions was observed. Results： The total effective rate was 97.87% in the observation group，higher than that of 82.98% in the control group (P＜0.05). After treatment，the scores of coughing， fear of cold， and expectoration as well as and the total scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above scores in the observation group were lower than those in the control group (P＜0.05). After treatment， forced vital capacity (FVC)， forced expiratory volume at the first second (FEV1)，and FEV1/FVC in the two groups were increased when compared with those before treatment (P＜0.05)， and the levels of FEV1， FVC， and FEV1/FVC in the observation group were higher than those in the control group (P＜0.05). After treatment， the levels of tumor necrosis factor- α (TNF- α)，interleukin- 4 (IL- 4)，and interleukin- 6 (IL- 6) in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of TNF- α，IL- 4，and IL- 6 in the observation group were lower than those in the control group (P＜0.05). The incidence of adverse reactions was 4.26% in the observation group，lower than that of 19.15% in the control group (P＜ 0.05). Conclusion： San'ao Tablets combined with routine western medicine has a good curative effect in the treatment of acute exacerbation of chronic bronchitis in senile patients，which can reduce their clinical symptoms， effectively improve lung function， and reduce the levels of serum inflammatory factors with good safety.