Abstract： Objective： To observe the curative effect of point massage for conducting yang into yin combined with Chinese medicine five-element music therapy on insomnia of heart-kidney non-interaction type. Methods：A total of 120 cases of patients with insomnia were selected and divided into the control group and the study group according to the random number table method， with 60 cases in each group. The control group was treated with sleep guidance and Estazolam Tablets， and the study group was additionally treated with point massage for conducting yang into yin combined with Chinese medicine fiveelement music therapy based on the treatment of the control group. Clinical effects were evaluated in the two groups. The total traditional Chinese medicine (TCM) syndrome scores，Pittsburgh Sleep Quality Index (PSQI) scores， and the levels of interleukin- 1β (IL- 1β) and 5- hydroxytryptamine (5- HT) in serum were compared between the two groups. Results： The total effective rate was 91.38% in the study group， higher than that of 68.42% in the control group (P＜0.05). After treatment，TCM syndrome scores and PSQI scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and the TCM syndrome scores and PSQI scores in the study group were lower than those in the control group (P＜ 0.05). After treatment， the levels of IL- 1β and 5- HT in serum in the two groups were increased when compared with those before treatment (P＜0.05)，and the two levels in the study group were higher than those in the control group (P＜0.05). Conclusion： Point massage for conducting yang into yin combined with Chinese medicine five-element music therapy has a better effect on patients with insomnia of heartkidney non-interaction type，and can significantly up-regulate the levels of IL-1β and 5-HT in serum and effectively improve clinical symptoms and sleep conditions.