Abstract：Objective：To observe the curative effect of the therapy of Compound Danshen Injection combined with modified Fuyuan Huoxue Decoction on coronary heart disease complicated with acute congestive heart failure based on routine therapy of modern medicine. Methods：A total of 80 patients with coronary heart disease complicated with acute congestive heart failure with qi deficiency and blood stasis syndrome were included as the study objects and randomly divided into the control group and the observation group， with 40 cases in each group. The two groups were given routine symptomatic treatment of modern medicine， and the observation group was additionally treated with Compound Danshen Injection combined with modified Fuyuan Huoxue Decoction. The two groups were treated for one month. Before and after treatment，the indexes of vascular endothelial function，including endothelin-1 (ET- 1)， plasma angiotensin Ⅱ (Ang Ⅱ)， calcitonin gene related peptide (CGRP) and nitric oxide (NO)， parameters of myocardial energy metabolism， including lactic acid (LA)， lactate dehydrogenase (LDH)， free fatty acid (FFA) and uric acid (UA)，and parameters of ventricular remodeling，including left ventricular fractional shortening (LVFS)，left ventricular posterior wall thickness (LVPWT)，interventricular septal end- systolic thickness (IVSS) and left ventricular mass index (LVMI) were detected，and the clinical effects were compared between the two groups. Results：After treatment，the total clinical effective rate was 95.00% in the observation group，higher than that of 77.50% in the control group，the difference being significant (P＜0.05). The levels of serum ET-1 and AngⅡin both groups were decreased when compared with those before treatment， and the levels of CGRP and NO were increased when compared with those before treatment，differences being significant (P＜0.05)；the levels of serum ET-1 and AngⅡin the observation group were lower than those in the control group，and the levels of CGRP and NO were higher than those in the control group，differences being significant (P＜0.05). The levels of serum LA，LDH，FFA and UA in the two groups were lower than those before treatment，differences being significant (P＜0.05)；the above four levels in the observation group were lower than those in the control group， differences being significant (P＜0.05). The values of LVFS in both groups were higher than those before treatment，and the values of LVPWT，IVSS and LVMI were lower than those before treatment，differences being significant (P＜0.05)；the value of LVFS in the observation group was higher than that in the control group，and the values of LVPWT，IVSS and LVMI were lower than those in the control group，differences being significant (P＜0.05). Conclusion： Based on the routine therapy of modern medicine， the additional application of Compound Danshen Injection combined with modified Fuyuan Huoxue Decoction can effectively improve the heart function of patients with coronary heart disease complicated with acute congestive heart failure syndrome with qi deficiency and blood stasis，and its mechanism may be related to the improvement of vascular endothelial function， adjustment of myocardial energy metabolism and inhibition of ventricular remodeling.