疏风解毒胶囊治疗慢性阻塞性肺疾病急性加重期临床研究
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Clinical Study on Shufeng Jiedu Capsules for Acute Exacerbation of Chronic Obstruc⁃ tive Pulmonary DiseaseClinical Study on Shufeng Jiedu Capsules for Acute Exacerbation of Chronic Obstruc⁃ tive Pulmonary Disease
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    目的:观察疏风解毒胶囊治疗慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效及对炎症因 子、肺功能的影响。方法:选取 100 例 AECOPD 患者,按照随机数表法分为观察组和对照组各 50 例。对照组 给予西医常规治疗,观察组在对照组治疗的基础上加用疏风解毒胶囊口服。2 组均以 7 d 为 1 个疗程,治疗 1 个疗程后比较 2 组肺功能指标[第 1 秒用力呼气容积(FEV 1 )、FEV 1 /用力肺活量(FVC)]、炎症因子[白细胞 介素(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏 C-反应蛋白(hs-CRP)]水平以及临床疗效。结果:观察组 总有效率为 92.00%,对照组为 76.00%,2 组比较,差异有统计学意义(P<0.05)。治疗后,2 组血清 IL-6、 hs-CRP、TNF-α 水平均较治疗前下降 (P<0.05),且观察组上述各项指标均低于对照组 (P<0.05)。治疗 后,2 组 FEV 1 、FEV 1 /FVC 水平均较治疗前升高(P<0.05),且观察组 2 项指标均高于对照组(P<0.05)。结 论:疏风解毒胶囊治疗 AECOPD 疗效显著,可下调血清炎症因子水平,有效改善患者肺功能。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Shufeng Jiedu Capsules for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and its effect on inflammatory factors and lung function. Methods:A total of 100 cases of AECOPD patients were selected and divided into the observation group and the control group according to the random number table method,with 50 cases in each group. The control group was given routine western medicine treatment,and the observation group was additionally given the oral administration of Shufeng Jiedu Capsules based on the treatment of the control group. Both groups were treated for seven days as a course of treatment. After one course of treatment,the levels of lung function indexes [forced expiratory volume in the first second (FEV 1 ),FEV 1 /forced vital capacity (FVC)], inflammatory factors [interleukin-6 (IL-6),tumor necrosis factor-α (TNF-α),hypersensitive C-reactive protein (hs-CRP)],and the clinical effects were compared between the two groups. Results:The total effective rate was 92.00% in the observation group and 76.00% in the control group,the difference being significant (P<0.05). After treatment,the levels of IL-6,hs-CRP,and TNF-α in serum in the two groups were decreased when compared with before treatment (P<0.05), and the above indexes in the observation group were lower than those in the control group (P<0.05). After treatment,the levels of FEV 1 and FEV 1 /FVC in the two groups were increased when compared with those before treatment (P<0.05), and the above two indexes in the observation group were higher than those in the control group (P<0.05). Conclusion:Shufeng Jiedu Capsules has a significant curative effect in the treatment of AECOPD,which can reduce the levels of inflammatory factors in serum and effectively improve the lung function of patients.

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王卫彪,李岱,滕鸿,沈林华,韩红燕,王尧坤.疏风解毒胶囊治疗慢性阻塞性肺疾病急性加重期临床研究[J].新中医,2023,55(14):43-46

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  • 在线发布日期: 2023-07-24
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