Abstract：Objective：To observe the clinical effect of Kangmin Zhenke Prescription for cough variant asthma (CVA) with wind pathogen adhering lung syndrome. Methods：A total of 68 cases of CVA patients with wind pathogen adhering lung syndrome were randomly divided into the control group and the observation group，with 34 cases in each group. The control group was treated with Montelukast Sodium Tablets， and the observation group was treated with Kangmin Zhenke Prescription. Both groups were treated for 2 weeks. Before and after treatment，Visual Analogue Scale (VAS) was applied to score the cough scores，to detect the indexes of lung function including forced expiratory volume in one second (FEV 1 )， ratio of forced expiratory volume in one second to forced vital capacity (FEV 1 /FVC)， maximal expiratory flow at 50% of the forced vital capacity (MEF50)，and maximal expiratory flow at 25% of the forced vital capacity (MEF25)，and to detect the levels of substance P (SP) in serum and bronchoalveolar lavage fluid. Results：After treatment，the scores of cough during daytime and at night in the two groups were decreased when compared with those before treatment (P＜0.05). The scores of cough during daytime and at night in the observation group were lower than those in the control group (P＜0.05). The values of FEV 1 ，FEV 1 /FVC，MEF50，and MEF25 in the observation group were higher than those before treatment (P＜0.05)，the values of FEV 1 ，MEF50，and MEF25 in the control group were higher than those before treatment (P＜0.05)，and the four values in the observation group were higher than those in the control group (P＜0.05). The SP levels in serum and bronchoalveolar lavage fluid in the two groups were decreased when compared with those before treatment (P＜0.05)， and the SP levels in serum and bronchoalveolar lavage fluid in the observation group were lower than those in the control group (P＜0.05). Conclusion：Kangmin Zhenke Prescription can effectively relieve cough in CVA patients with wind pathogen adhering lung syndrome， and improve their lung function， which may be related to reducing airway inflammation and reducing airway hyperresponsiveness.