Abstract：Objective：To observe the clinical effect of Jiedu Huapi Ointment combined with Shugan Jiangzhi Tablets for nonalcoholic fatty liver disease (NAFLD). Methods：The medical records of 96 patients with NAFLD complicated with hypochondriac pain who were treated in The second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine) from July 2018 to July 2019 were collected. The patients were divided into the Jiedu Huapi Ointment group and the routine treatment group according to whether they were treated with Jiedu Huapi Ointment，with 63 and 32 cases in each group respectively. Both groups were treated with western medicine and routine nursing； the routine treatment group was additionally treated with Shugan Jiangzhi Tablets，and the Jiedu Huapi Ointment group was additionally treated with Jiedu Huapi Ointment based on the treatment of the routine treatment group. Both groups were treated for 12 weeks. The degree of hypochondriac pain [Visual Analogue Scale (VAS) scores]，blood lipid indexes [total cholesterol (TC)，triglyceride (TG)，low-density lipoprotein cholesterol (LDL-C)，and high-density lipoprotein cholesterol (HDL-C)]，severity of fatty liver [controlled attenuation parameter (CAP)]， liver function indexes [aspartate aminotransferase (AST) and alanine aminotransferase (ALT)]， and body mass index (BMI) were compared between the two groups before and after treatment. Results：After treatment，VAS scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and VAS score in the Jiedu Huapi Ointment group was lower than that in the routine treatment group (P＜0.05). The CAP values and levels of TC，TG，and LDL-C in the two groups were decreased when compared with those before treatment (P＜0.05)，and HDL-C levels were increased when compared with those before treatment (P＜0.05)；CAP value and levels of TC， TG，and LDL-C in the Jiedu Huapi Ointment group were lower than those in the routine treatment group (P＜0.05)，and HDL-C level was higher than that in the routine treatment group (P＜0.05). The levels of ALT and AST in serum，and BMI in the two groups were decreased when compared with those before treatment (P＜0.05)，and levels of ALT and AST in serum，and BMI in the Jiedu Huapi Ointment group were lower than those in the routine treatment group (P＜0.05). Conclusion： Jiedu Huapi Ointment combined with Shugan Jiangzhi Tablets can effectively relieve the symptom of hypochondrium pain in NAFLD patients and reduce levels of blood lipid，whose effect is better than that of simple Shugan Jiangzhi Tablets.