Abstract：Objective：To observe the effect of hot pack with Sizi Powder combined with joint range of motion training on limb function in patients with peripherally inserted central catheters (PICC). Methods：A total of 98 cases of patients with PICC were divided into the observation group and the control group according to the random number table method，with 49 cases in each group. The control group was given measures of routine care and maintenance of PICC，and the observation group was additionally treated with the hot pack with Sizi Powder combined with joint range of motion training based on the treatment of the control group. The grip strength of affected limbs，the blood flow rates of axillary vein，limb function，and the incidence of adverse events of PICC were compared between the two groups before and after treatment. Results：After treatment，the grip strength of affected limbs and the blood flow rates of axillary vein in the two groups were increased when compared with those before treatment (P＜0.05)，and the grip strength of affected limbs and the blood flow rate of axillary vein in the observation group were greater than those in the control group (P＜0.05). After treatment，the scores of Constant-Murley for shoulder joint in the two groups were increased when compared with those before treatment (P＜0.05)，and the scores in the observation group were higher than those in the control group (P＜0.05)； there was no significant difference being found in the comparison of Cooney scores for wrist joints function and Mayo scores for elbow joint function in the two groups before treatment and after treatment (P＞0.05). The incidence of adverse events of PICC was 6.12% in the observation group and 20.41% in the control group， the difference being significant (P＜0.05). Conclusion：Hot pack with Sizi Powder combined with joint range of motion training can promote blood circulation in patients' limbs，effectively maintain normal wrist and elbow joint function of patients with PICC，improve shoulder joint function，and reduce the incidence of adverse events caused by PICC.