Abstract： Objective： To study the active components， targets and pathways of Qingwen Baidu Decoction in the treatment of Kawasaki disease (KD)，Henoch-schonlein purpura (HSP) and systemic lupus erythematosus (SLE)，through the network pharmacology and molecular docking method，based on the theory of "treating different diseases with same method" in traditional Chinese medicine (TCM)，so as to provide theoretical basis for basic research and clinical application for these diseases. Methods：The targets of Qingwen Baidu Decoction selected from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) and the Encyclopedia of Traditional Chinese Medicine (ETCM) databases were intersected with KD，HSP and SLE disease targets obtained from Gencards and OMIM databases. The protein-protein interaction (PPI) diagram was drawn by using String database and Cytoscape，and the core targets were obtained by CytoHubba analysis. DAVID database and R language were used to conduct GO and KEGG enrichment analysis. Core components were obtained by constructing drug-component- target- pathway network diagram through Cytascape. AutoDock and PyMOL were used for molecular docking. Results：There were six active components in Qingwen Baidu Decoction that can simultaneously affect KD， HSP and SLE by regulating 38 targets and 123 pathways. Mainly Quercetin， Apigenin， Kaempferol，Luteolin，β-sitosterol，Baicalin，which played the therapeutic role by acting on lipid and atherosclerosis pathways， cancer pathways and other pathways through the core targets such as interleukin- 6， vascular endothelial growth factor， and peroxidase proliferators γ， etc. The molecular docking results suggested that most of the targets and components have good binding activity. Conclusion： The "treating different diseases with same method" for KD，HSP，and SLE of Qingwen Baidu Decoction have the characteristics of multiple components，multiple effective targets，and coordinated effects of multiple pathways. It also confirms the scientific and effective nature of the TCM theory of "treating different diseases with same method" has provided new ideas for further basic research and clinical trials on the treatment of KD，HSP，and SLE.