Abstract：Objective：To observe the clinical effect of Guanxinning Pills combined with routine western medicine for myocardial infarction with non-obstructive coronary arteries (MINOCA). Methods：A total of 60 cases of MINOCA patients were selected and divided into the observation group and the control group according to the random number table method，with 30 cases in each group. The control group was treated with routine western medicine，and the observation group was additionally treated with Guanxinning Pills based on the treatment of the control group. The changes in angina pectoris symptoms，cardiac function indicators，sleep quality，and electrocardiogram were compared before and after treatment between the two groups. The incidence of cardiovascular events in the two groups was counted. Results：The total curative effective rate of electrocardiogram was 96.67% in the observation group， higher than that of 80.00% in the control group (P＜0.05). After treatment， the scores of angina pectoris symptoms and Pittsburgh Sleep Quality Index (PSQI) in the two groups were decreased when compared with those before treatment (P＜0.05)，and the scores of angina pectoris symptoms and PSQI in the observation group were lower than those in the control group (P＜0.05). After treatment，the levels of cardiac troponin I (cTnI)， creatine kinase-MB (CK-MB)，and N-terminal pro B-type natriuretic peptide (NT-proBNP) in the two groups were decreased when compared with those before treatment (P＜0.05)，and the the three levels in the observation group were lower than those in the control group (P＜0.05). The incidence of cardiovascular events was 6.67% in the observation group，lower than that of 26.67% in the control group，the difference being significant (P＜0.05). Conclusion： Guanxinning Pills combined with routine western medicine has relatively high curative effects and safety in the treatment of MINOCA，and can effectively alleviate heart ischemia in patients， improve angina pectoris symptoms， enhance sleep quality， and reduce the incidence of cardiovascular events.