Abstract： Objective： To observe the clinical effect of therapy of Yiqi Yangyin Huashi Prescription combined with fasting treatment in Chinese medicine on metabolic syndrome of spleen deficiency with phlegm-damp type. Methods：A total of 90 patients with metabolic syndrome of spleen deficiency with phlegm-damp type were selected and divided into the observation group and the control group according to the random number table method，with 45 cases in each group. The control group was given western medicine for treatment，and the observation group was additionally treated with therapy of Yiqi Yangyin Huashi Prescription combined with fasting treatment in Chinese medicine based on the treatment of the control group. After 12 weeks of treatment，the clinical effects was compared between the two groups. And the traditional Chinese medicine (TCM) syndrome scores，waistline，body mass index (BMI)，blood pressure，blood sugar，blood fat and levels of serum inflammatory factors compared were before and after treatment between the two groups. Results： The total effective rate was 91.11% in the observation group， higher than that of 73.33% in the control group (P＜0.05). Before treatment， there was no significant difference being found in the comparison of TCM syndrome scores between the two groups (P＞ 0.05)；after treatment，the TCM syndrome scores in the two groups were decreased (P＜0.05)，and the TCM syndrome score in the observation group was lower than that in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparisons of waistline，BMI，systolic pressure and diastolic pressure between the two groups (P＞0.05)；after treatment，the waistline，BMI， systolic pressure and diastolic pressure in the two groups were decreased (P＜0.05)，and the above four levels in the observation group were lower than those in the control group (P＜0.05). Before treatment， there was no significant difference being found in the comparisons of levels of fasting blood glucose (FBG)， triglyceride(TG)，total cholesterol(TC)，high density lipoprotein cholesterol(HDL-C)，low density lipoprotein cholesterol(LDL- C) and plasma atherogenic index (AIP) between the two groups (P＞0.05)； after treatment，the levels of FBG，TG，TC，LDL-C and AIP in both groups were decreased (P＜0.05)，and the above five levels in the observation group were lower than those in the control group (P＜0.05). Before and after treatment，there was no significant difference being found in the comparison of HDL-C level between the two groups (P＞0.05). Before treatment，there was no significant difference being found in the comparisons of levels of serum tumor necrosis factor-α(TNF-α)，high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) between the two groups (P＞0.05)；after treatment，the levels of serum TNF-α，hs-CRP and IL-6 in both groups were decreased (P＜0.05)，and the above three levels in the observation group were lower than those in the control group (P＜0.05). Conclusion：The therapy of Yiqi Yangyin Huashi Prescription combined with fasting treatment in Chinese medicine has a significant curative effect on metabolic syndrome of spleen deficiency with phlegm-damp type，which can effectively improve the clinical symptoms，regulate the metabolic disorder and reduce the inflammatory responses.