Abstract：Objective：To observe the clinical effect of the therapy of Lishi Huoxue Tongluo Prescription combined with Adamumab on rheumatoid arthritis of damp-heat stasis obstruction type. Methods：A total of 124 cases with rheumatoid arthritis of damp-heat stasis obstruction type were divided into the control group and the observation group according to random number table method，with 62 cases in each group. The control group was treated with Adamumab，and the observation group was additionally treated with Lishi Huoxue Tongluo Prescription based on the treatment of the control group. The traditional Chinese medicine (TCM) syndrome scores，inflammation indexes，hemorheology indexes，Clinical Disease Activity Index (CDAI)，Visual Analogue Scale (VAS)，Lysholm knee scale score were compared before and after treatment between the two groups. The clinical effect and the occurrence of adverse reactions were evaluated in both groups. Results：The total effective rate was 91.94% in the observation group，higher than that of 77.42% in the control group (P＜0.05). After treatment，the TCM syndrome scores and the scores of CDAI and VAS in the two groups were decreased when compared with those before treatment (P＜0.05)，and the Lysholm knee scale scores were increased (P＜0.05)；the TCM syndrome score and scores of CDAI and VAS in the observation group were lower than those in the control group (P＜0.05)，and the Lysholm knee scale score was increased (P＜0.05). After treatment，the cyclic citrullinated peptide (CCP)，human epididymal protein 4 (HE4)，Nod-like receptor protein 3 (NLRP3)，whole blood viscosity (WBV)，D-dimer (D-D)，fibrinogen (FIB) and Erythrocyte Aggregation Index (EAI) in the two groups were all decreased when compared with those before treatment (P＜0.05)，and the inflammation indexes and hemorheology indexes in the observation group were lower than those in the control group after treatment (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion：The therapy of Lishi Huoxue Tongluo Prescription combined with Adamumab has a definite clinical effect on the treatment of rheumatoid arthritis of damp-heat stasis obstruction type，which can reduce the levels of inflammatory factors and improve hemorheology indexes in patients，with great safety.