Abstract： Objective： To observe the clinical effect of therapy of throat insufflation combined with modified Ganlu Xiaodu Pellets on herpetic angina in children. Methods：A total of 120 children with herpetic angina were selected as the study objects and divided into the control group and the observation group according to the random number table method，with 60 cases in each group. The condition of children in the two groups was closely observed，and common and symptomatic treatment was given accordingly. The observation group was given insufflation of Bingqing Powder into the throat with special tool for children combined with oral administration of modified Ganlu Xiaodu Pellets. The control group was treated with therapy of Recombinant Human Interferon- α2b Spraying Agent combined with Xiao'er Chiqiao Qingre Granules. The clinical effects，improvement time of symptoms，incidence of adverse reactions，traditional Chinese medicine (TCM) syndrome scores，and changes of serum inflammatory indicators and immune function indexes were compared before and after treatment between the two groups. Results：The cure rate and effective rate were 41.67% and 98.33% in the observation group，respectively，higher than those of 15.00% and 88.33% in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparison of TCM syndrome score between the two groups (P＞0.05)； after treatment，the TCM syndrome scores in both groups were decreased (P＜0.05)，and the TCM syndrome score in the observation group was lower than that in the control group (P＜0.05). The recovery time of normal body temperature， food intake and sleep， and disappearance time of herpes， drooling and symptoms of digestive tract in the observation group were less than those in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparisons of levels of serum white blood cell count (WBC)，neutrophil count (NEUT)，C-reactive protein (CRP) and white blood cell count-6(IL-6) between the two groups (P＞0.05)；after treatment，the levels of serum WBC，NEUT， CRP and IL-6 in both groups were decreased (P＜0.05)，and the above four levels in the observation group were lower than those in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparisons of levels of serum immunoglobulin A(IgA)，immunoglobulin G (IgG) and immunoglobulin M (IgM) between the two groups (P＞0.05)；after treatment，the levels of serum IgA and IgG in both groups were increased (P＜0.05)，the IgM levels were decreased，and the levels of serum IgA and IgG in the observation group were higher than those in the control group (P＜0.05). Before treatment， there was no significant difference being found in the comparisons of CD4 + ，CD8 + and CD4 + /CD8 + between the two groups (P＞0.05)；after treatment，the CD4 + and CD4 + /CD8 + in the two groups were increased (P＜ 0.05)，the CD8 + was decreased (P＜0.05)；the CD4 + and CD4 + /CD8 + in the observation group were higher than those in the control group (P＜0.05)，and the CD8 + was lower than that in the control group (P＜0.05). There was no significant difference being found in the comparison of incidence of adverse reactions between the two groups (P＞0.05). Conclusion：The therapy of throat insufflation combined with modified Ganlu Xiaodu Pellets has a significant curative effect on herpetic angina in children，which can shorten the recovery time of herpetic herpes， improve the appetite and sleep， accelerate the disappearance of symptoms of digestive tract，regulate the immune function of the body，and mitigate the inflammatory responses with good safety.