Abstract： Guillain- Barré syndrome (GBS) is a common autoimmune peripheral neuropathy in neurology. The pathogenesis of GBS is not yet fully clear，and clinical treatment is limited to immunoglobulin and plasma exchange. However，immune cell imbalance and dysfunction of immune function impenetrate the entire course of the disease，and multi-protocol immune regulation has become a research hotspot in GBS treatment. Chinese medicine has unique advantages in health preservation，disease prevention，and immune regulation. This article elucidates the correlation between the spleen as the guardian of the body， the spleen governing transportation and transformation，and western medicine immunity，discusses the fundamental pathogenesis of GBS immune disorders from the perspective of spleen deficiency，and adopts the methods of tonifying the spleen and boosting qi，activating the spleen and removing dampness，and tonifying the spleen and warming the kidney to treat GBS.