Abstract：Objective：To observe the clinical effect of Modified Huangqi Jianzhong Decoction combined with western medicine for peptic ulcer with spleen-stomach deficiency cold syndrome. Methods：A total of 89 cases of patients with peptic ulcer with spleen-stomach deficiency cold syndrome were divided into the control group and the trial group according to the random number table method，with 45 and 44 cases in each group respectively. The control group was treated with routine western medicine，and the trial group was additionally treated with Modified Huangqi Jianzhong Decoction based on the treatment of the control group. Traditional Chinese medicine (TCM) syndrome scores，ulcer area，and the levels of immunoglobulin and inflammatory factors in serum were compared before and after treatment between the two groups. The clinical effects，the eradication rates of Helicobacter pylori (Hp) and the incidence of adverse reactions were compared between the two groups. Results：The total effective rate was 95.45% in the trial group，higher than that of 77.78% in the control group (P＜0.05). After treatment， the TCM syndrome scores， ulcer area and the levels of procalcitonin (PCT)，interleukin-6 (IL-6)，and hypersensitive C-reactive protein (hs- CRP) in serum in the two groups were decreased when compared with those before treatment (P＜0.05)， and the TCM syndrome score，ulcer area，and inflammatory factor levels in the trial group were lower than those in the control group (P＜0.05). After treatment， the levels of immunoglobulin G (IgG)， immunoglobulin A (IgA)，and immunoglobulin M (IgM) in the two groups were increased when compared with those before treatment (P＜0.05)，and the above immunoglobulin levels in the trial group were higher than those in the control group (P＜0.05). There was no significant difference being found in the comparison of Hp eradication rates between the two groups (P＞0.05). The incidence of adverse reactions in the trial group was 4.55% ， lower than that of 26.67% in the control group (P＜0.05). Conclusion： Modified Huangqi Jianzhong Decoction combined with western medicine has a definite curative effect in the treatment of peptic ulcer with spleen-stomach deficiency cold syndrome，which can improve the immune levels of patients and reduce inflammatory responses and ulcer area，with high safety.