Abstract：Objective：To observe the clinical effect of Senate Ligusticum Glucose Injection combined with low molecular weight heparin for acute cerebral infarction (ACI). Methods：A total of 63 cases of ACI patients were divided into the A group and the B group according to the random number table method，with 31 and 32 cases in each group respectively. The A group was treated with low molecular weight heparin， and the B group was treated with Senate Ligusticum Glucose Injection based on the treatment of the A group. Both two groups were treated for 15 days. Before and after treatment，traditional Chinese medicine (TCM) syndrome scores，average cerebral blood flow velocity，Barthel Index，National Institutes of Health Stroke Scale (NIHSS) scores were compared between the two groups. The clinical effects and adverse reactions were compared between the two groups. Results：The total effective rate was 96.88% in the B group， higher than that of 77.42% in the A group (P＜0.05). Before treatment， there was no significant difference being found in the comparison of TCM syndrome scores between the two groups (P＞0.05). After treatment， the TCM syndrome scores including giddy and dazzled， hemiplegia， hemianesthesia， and white greasy tongue coating in the two groups were decreased (P＜0.05)，and the scores in the B group were lower than those in the A group (P＜0.05). Before treatment， there was no significant difference being found in the comparison of scores of Barthel Index and NIHSS between the two groups (P＞0.05). After treatment， scores of Barthel Index in the two groups were increased when compared with those before treatment (P＜0.05)，NHISS scores were decreased (P＜0.05)；the score of Barthel Index in the B group was higher than that in the A group (P＜0.05)， and the NIHSS score was lower than that in the A group (P＜0.05). Before treatment， there was no significant difference being found in the comparison of mean blood velocity of middle artery， anterior artery， and posterior artery between the two groups (P＞ 0.05). After treatment，the mean blood velocity of middle artery，anterior artery，and posterior artery in the two groups were increased (P＜0.05)，and the ones in the B group were larger than those in the A group (P＜0.05). The total incidence of adverse reactions in the B group was lower than that in the A group (χ 2= 6.907，P=0.009). Conclusion：The combination of Senate Ligusticum Glucose Injection and low molecular weight heparin has an ideal curative effect on ACI patients， which can improve symptoms， neurological function and quality of life，and regulate cerebral blood flow velocity，which is safer.