Abstract： Objective： To observe the clinical effect of modified Yishen Jianpi Decoction in adjuvant therapy of diabetic kidney disease of spleen-kidney yang deficiency type. Methods：A total of 102 cases of patients with diabetic kidney disease of spleen- kidney yang deficiency type were divided into the control group and the treatment group according to the random number table method， with 51 cases in each group. The control group was treated with conventional western medicine，and the treatment group based on the treatment of the control group was additionally treated with modified Yishen Jianpi Decoction. Traditional Chinese medicine (TCM) syndrome scores，the kidney function indexes，blood glucose indexes and inflammatory factors were compared between the two groups before and after treatment. Clinical effects and medication safety were evaluated in the two groups. Results： The total effective rate of the treatment group was higher than that of the control group (P＜0.05). The TCM syndrome scores，24-hour urine protein quantification (24 h- UP)，serum creatinine (SCr)，and blood urea nitrogen (BUN) in the two groups after treatment were decreased when compared with those before treatment (P＜0.05)， and the TCM syndrome scores and kidney function indexes in the treatment group after treatment were lower than those in the control group (P＜0.05). The fasting blood glucose (FBG)，2- hour postprandial blood glucose (P2hBG)， glycosylated hemoglobin (HbAlc)， C- reactive protein (CRP)， interleukin- 6 (IL- 6) and tumor necrosis factor- α (TNF- α) in the two groups after treatment were decreased when compared with those before treatment (P＜0.05)，and the above blood glucose indexes and inflammatory factors in the treatment group after treatment were lower than those in the control group (P＜0.05). There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups (P＞ 0.05). Conclusion： Modified Yishen Jianpi Decoction in adjuvant therapy of diabetic kidney disease of spleen- kidney yang deficiency type can effectively improve the kidney function， alleviate inflammatory responses and lower blood sugar，with a significant curative effect and high safety.