Abstract： Objective： To observe the clinical effect of Huang'e Capsules combined with western medicine for benign prostatic hyperplasia (BPH). Methods： A total of 100 cases of BPH patients were selected as the study objects and divided into the control group and the treatment group according to the random number table method， with 50 cases in each group. The control group was given Tamsulosin Hydrochloride Oral Dispersible Sustained Release Tablets and Dutasteride Soft Capsules， and the treatment group was additionally treated with Huang'e Capsules based on the treatment of the control group. After six treatment courses，clinical effects，International Prostatism Symptom Score (IPSS)，the Quality of Life Scale for Benign Prostatic Hyperplasia Patient (BPHQLS)，the ability to control urination，and the levels of sex hormone indicators serum estradiol (E2) and testosterone (T) were evaluated in the two groups. Results： The total effective rate was 94.00% in the treatment group and 72.00% in the control group， the difference being significant (P＜0.05). After treatment， IPSS scores， residual urine volume， and prostate volume in the two groups were decreased when compared with those before treatment (P＜ 0.05)，and the maximal urinary flow rates were increased when compared with those before treatment (P＜ 0.05)； the improvement of above indexes in the treatment group was more significant than that in the control group (P＜0.05). After treatment，the levels of E2 in serum in the two groups were increased when compared with those before treatment (P＜0.05)，and the level of E2 in the treatment group was higher than that in the control group (P＜0.05)；there was no significant difference being found in the comparison of T level in serum in the two groups before and after treatment (P＞0.05). After treatment， the scores of disease， psychology， physology， satisfaction， and social in BPHQLS and the total scores in the two groups were increased when compared with those before treatment (P＜0.05)，and the above scores in the treatment group were higher than those in the control group (P＜0.05). Conclusion： Huang'e Capsules combined with western medicine has a significant curative effect in the treatment of BPH and can effectively regulate the levels of sex hormones， which is beneficial for alleviating the symptoms of the patient's prostate and improving the ability to control urine and quality of life.