Abstract： Objective： To observe the clinical effect of orthopedic tuina for simple disc herniation and its effect on levels of interleukin- 1β (IL- 1β) and hypersensitive C- reactive protein (hs- CRP) in serum. Methods：A total of 166 cases of patients with simple disc herniation were randomly divided into the control group and the observation group，with 83 cases in each group. The control group was treated with routine lumbar traction，and the observation group was treated with orthopedic tuina. The Japanese Orthopaedic Association Assessment Scale (JOA) scores， Visual Analogue Scale (VAS) scores of pain， IL- 1β levels， hs-CRP levels，and clinical effects were compared between the two groups. Results：The total effective rate was 89.16% in the observation group and 74.70% in the control group，the difference being significant (P＜0.05). Before treatment， there was no significant difference being found in the comparison of the scores of subjective symptoms，clinical signs，and limitations on daily activities in JOA scale between the two groups (P＞0.05). After treatment，the scores of subjective symptoms，clinical signs，and limitations on daily activities in JOA scale in the two groups were increased when compared with those before treatment (P＜0.05)，and the above scores in the observation group were higher than those in the control group (P＜0.05). Before treatment， there was no significant difference being found in the comparison of VAS scores between the two groups (P＞0.05). After treatment， VAS scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and VAS score in the observation group was lower than that in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of IL- 1β and hs-CRP in serum between the two groups (P＞ 0.05). After treatment，the levels of IL-1β and hs-CRP in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of IL-1β and hs-CRP in the observation group were lower than those in the control group (P＜0.05). Conclusion： Orthopedic tuina has a significant curative effect in the treatment of simple disc herniation， which can reduce inflammation， effectively improve lumbar function，and relieve symptoms of lumbago.