Abstract： Traditional Chinese medicine believes that the ascending and descending of qi movement maintains the life activities of the human body and plays an important role in balancing the internal environment of the body. If there is a disturbance in the ascending and descending of qi movement，the metabolism of qi，blood，and fluids will be abnormal，and pathological products such as phlegm，damp， fire， and blood stasis will produce， and the internal environment of the gut microbiota will change， resulting in a metabolic disorder of gut microbiota and affecting the occurrence and development of coronary heart disease. Based on theory of ascending and descending of qi movement， the authors analysis the relationship between gut microbiota and coronary heart disease， with an aim to provide ideas for clinical diagnosis and treatment of coronary heart disease.