Abstract： Objective： To observe the clinical effect of the therapy of modified Huanglian E'jiao Decoction combined with Mifepristone on dysfunctional uterine bleeding during perimenopause of failure of the heart and kidney to interact type. Methods：A total of 118 patients with dysfunctional uterine bleeding during perimenopause of non-interaction between the heart and kidney type were divided into the observation group and the control group according to the random number table method，with 59 cases in each group. The control group was given administration of Mifepristone Tablets，and the observation group was additionally treated with modified Huanglian E'jiao Decoction based on the treatment of the control group. The clinical effects， symptom control time and incidence of adverse reactions were compared between the two groups， and before and after treatment， the traditional Chinese medicine (TCM) syndrome scores， uterine ultrasound indexes， sex hormone indexes and T cell subsets were also compared between the two groups. Results：After treatment，the total effective rate was 93.22% in the observation group，higher than that of 76.27% in the control group (P＜0.05). The bleeding control time， complete hemostasis time and abdominal pain relief time in the observation group were shorter than those in the control group (P＜0.05). After treatment，the endometrial thickness and the TCM syndrome scores in the two groups were decreased when compared with those before treatment (P＜0.05)， and the contraction amplitude and frequency of uterine smooth muscle were increased (P＜0.05)；after treatment， the endometrial thickness and the TCM syndrome scores in the observation group were thinner or lower than those in the control group (P＜0.05)，and the contraction amplitude and frequency of uterine smooth muscle were higher than those in the control group (P＜0.05). After treatment，the levels of estradiol (E2)， follicle-stimulating hormone (FSH)，luteinizing hormone (LH) and CD8+ in the two groups were decreased when compared with those before treatment (P＜0.05)， and the levels of the above sex hormones and CD8 + in the observation group were lower than those in the control group (P＜0.05). After treatment，the levels of CD3+，CD4+ and CD4+/CD8+ in the two groups were increased when compared with those before treatment (P＜0.05)，and the levels of CD3 +，CD4 + and CD4 +/CD8 + in the observation group were higher than those in the control group (P＜0.05). The incidence of adverse reactions in the observation group was lower than that in the control group (P＜0.05). Conclusion： The therapy of modified Huanglian E'jiao Decoction combined with Mifepristone has a definite therapeutic effect on treating dysfunctional uterine bleeding during perimenopause of non- interaction between the heart and kidney type ， which can effectively inhibit the secretion of sex hormones and improve immune function，with high safety.