乌灵胶囊联合认知行为疗法治疗帕金森病睡眠障碍临床研究
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R742.5;R740

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浙江省医学会临床科研项目(2021ZYC-B04);温州市基础性科研项目(Y2020428)


Clinical Study on Wuling Capsules Combined with Cognitive Behavioral Therapy for Sleep Disorders in Parkinson's Disease
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    摘要:

    目的:观察乌灵胶囊联合认知行为疗法对帕金森病睡眠障碍的疗效。方法:选取60 例帕金森病伴 睡眠障碍患者,按随机数字表法分为试验组及对照组各30 例。对照组采用认知行为疗法治疗,试验组采用乌 灵胶囊联合认知行为疗法治疗。比较2 组治疗前后帕金森病睡眠量表(PDSS)、帕金森病生活质量问 卷(PDQ-8) 评分的变化,比较试验组治疗前后PDSS 睡眠质量各项目评分的变化。结果:治疗后,2 组PDSS 睡眠质量评分均较治疗前上升(P<0.05),试验组PDSS 睡眠质量评分高于对照组(P<0.05)。治疗后,试验 组PDSS 睡眠质量PDSS-1 (睡眠总体质量)、PDSS-2 (入睡)、PDSS-3 (睡眠维持)、PDSS-6 (夜间噩梦)、 PDSS-13 (醒来颤抖)、PDSS-14 (日间疲乏、嗜睡) 项评分均较治疗前升高,差异均有统计学意义(P< 0.05)。治疗后,2 组PDQ-8 生活质量评分均较治疗前下降(P<0.05),试验组PDQ-8 生活质量评分低于对照 组(P<0.05)。结论:乌灵胶囊联合认知行为疗法治疗帕金森病睡眠障碍疗效较好,可改善患者生活质量。

    Abstract:

    Abstract: Objective: To observe the curative effect of Wuling Capsules combined with cognitive behavioral therapy for sleep disorders in Parkinson's disease. Methods:A total of 60 cases of patients with Parkinson's disease accompanied by sleep disorders were randomly divided into the trial group and the control group, with 30 cases in each group. The control group was treated with cognitive behavioral therapy,and the trial group was treated with Wuling Capsules combined with cognitive behavioral therapy. The changes in the scores of the Parkinson's Disease Sleep Scale (PDSS) and 8- item version of the Parkinson's Disease Questionnaire (PDQ- 8) were compared before and after treatment between the two groups. The changes in the scores of various items of sleep quality in PDSS were compared before and after treatment in the trial group. Results:After treatment,the scores of sleep quality in PDSS in the two groups were increased when compared with those before treatment (P<0.05),and the score of sleep quality in PDSS in the trial group was higher than that in the control group (P<0.05). After treatment,the scores of sleep quality in PDSS,including PDSS-1 (overall sleep quality),PDSS-2 (falling asleep),PDSS-3 (staying asleep),PDSS- 6 (distressing dreams),PDSS- 13 (waking tremor),and PDSS- 14 (fatigue and sleepy in the daytime) in the trial group were increased when compared with those before treatment,the differences being significant (P<0.05). After treatment,the scores of quality of life in PDQ-8 in the two groups were decreased when compared with those before treatment (P<0.05),and the score of quality of life in PDQ-8 in the trial group was lower than that in the control group (P<0.05). Conclusion:Wuling Capsules combined with cognitive behavioral therapy has a relatively good curative effect in treating sleep disorders in Parkinson's disease,and can improve quality of life.

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张雅西,林彩丹,黄向东.乌灵胶囊联合认知行为疗法治疗帕金森病睡眠障碍临床研究[J].新中医,2023,55(19):43-47

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  • 在线发布日期: 2023-10-17
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