Abstract： Objective： To observe the clinical effect of the therapy of Shugan Anshen Decoction combined with repetitive transcranial magnetic stimulation (rTMS) on generalized anxiety disorder (GAD) of liver constraint and qi stagnation type. Methods： A total of 80 GAD patients of liver constraint and qi stagnation type were given the retrospective analysis and divided into the control group and the treatment group according to different treatment methods，with 40 cases in each group. The two groups were given Paroxetine Hydrochloride for treatment， the control group was additionally treated with rTMS， and the treatment group was additionally given Shugan Anshen Decoction based on the treatment of the control group. Before and after treatment，the traditional Chinese medicine (TCM) syndrome scores，the scores of Hamilton Anxiety Scale (HAMA) and Self- rating Anxiety Scale (SAS) and the levels of serum inflammatory factors were compared between the two groups；the clinical effects and incidence of adverse reactions in both groups were evaluated. Results：There was no significant difference being found in the comparisons of total effective rate and incidence of adverse reactions between the two groups (P＞0.05). After treatment，the TCM syndrome scores，scores of HAMA and SAS and levels of serum C-reactive protein， interleukin-6 and interleukin-1α in both groups were lower than those before treatment (P＜0.05)，and the above indexes in the treatment group were lower than those in the control group (P＜0.05). Conclusion： The therapy of Shugan Anshen Decoction combined with rTMS has a definite curative effect on GAD of liver constraint and qi stagnation type，which can improve the anxiety symptoms of patients and down-regulate the levels of inflammatory levels with good safety.