Abstract：Objective：To observe the curative effect of Shenyanshu Tablets combined with Valsartan on chronic glomerulonephritis (CGN) and its effects on immunity function and kidney function. Methods： A retrospective analysis was conducted on 80 patients with CGN and they were divided into the control group and the treatment group according to different treatment methods， with 40 cases in each group. The control group was treated with Valsartan， and the treatment group was additionally treated with Shenyanshu Tablets based on the treatment of the control group. Clinical effects and the incidence of adverse reactions in the two groups were observed. The changes in kidney function indexes， including creatinine (Cr)，blood urea nitrogen (BUN) and 24-hour urinary protein content (24 hUPro)，cellular immune function indexes， including CD4 + ， CD8 + and CD4 +/CD8 + levels， and serum inflammatory (IL- 4， IL- 6、 TNF- α) indexes were compared between the two groups before and after treatment. Results： The total clinical effective rate was 80.00% in the control group and 95.00% in the treatment group，the difference being significant (P＜0.05). After treatment，CD4+ and CD4+/CD8+ levels in the two groups were increased when compared with those before treatment，and CD8 + levels were decreased (P＞0.05)；the CD4 + and CD4+/CD8+ levels in the treatment group were higher than those in the control group，and the CD8+ level in the treatment group was lower than that in the control group (P＜0.05). After treatment，the levels of Cr， BUN，and 24 hUPro in the two groups were decreased when compared with those before treatment (P＜ 0.05)，and the above three levels in the treatment group were lower than those in the control group (P＜ 0.05). After treatment，the IL-4 levels in the two groups were increased when compared with those before treatment，and the levels of IL-6 and TNF-α were decreased when compared with those before treatment (P＜0.05)；the IL-4 level in the treatment group was higher than that in the control group，and the levels of IL-6 and TNF-α in the treatment group were lower than those in the control group (P＜0.05). The incidence of adverse reactions was 10.00% in the control group and 5.00% in the treatment group，and there was no significant difference being found between the two groups (P＞0.05). Conclusion： The therapy of Shenyanshu Tablets combined with Valsartan has a relatively good curative effect on the treatment of CGN and can improve kidney function， regulate cellular immunity， and reduce inflammatory factors with high safety.