Abstract：Objective：To observe the effect of Shenyan'an Capsules combined with Cyclophosphamide on nephrotic syndrome (NS) and its effect on serum inflammatory factors. Methods：A total of 132 NS patients were divided into the treatment group and the control group according to the random number table method，with 66 patients in each group. The control group was treated with Cyclophosphamide，and the treatment group was additionally treated with Shenyan'an Capsules based on the treatment of the control group. Both groups were treated for one month. The clinical effects and incidence of adverse reactions in the two groups were observed in the two groups，and the coagulation indexes，including D-dimer (D-D) and fibrinogen (FIB)，kidney function indexes，including serum creatinine (SCr)，plasma albumin (Alb) and 24-hour urinary protein (24h Upro)，and inflammatory factor indexes，including C-reactive protein (CRP)， tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were compared between the two groups before and after treatment. Results：The total effective rate was 83.33% in the control group and 95.45% in the treatment group，the difference being significant (P＜0.05). After treatment，the levels of D-D and FIB in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of D-D and FIB in the treatment group were lower than those in the control group (P＜0.05). After treatment， the levels of SCr and 24 hUpro in the two groups were decreased when compared with those before treatment，and the Alb levels were increased when compared with those before treatment (P＜0.05)；the SCr and 24hUpro levels in the treatment group were lower than those in the control group (P＜0.05)，and the Alb level was higher than that in the control group (P＜0.05). After treatment，the levels of CRP，IL-6 and TNF-α in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above three levels in the treatment group were lower than those in the control group (P＜0.05). The incidence of adverse reactions was 4.55% in the control group and 3.03% in the treatment group， there being no significant difference between the two groups (P＞0.05). Conclusion：The therapy of Shenyan'an Capsules combined with Cyclophosphamide has a good clinical effect on NS，which can effectively improve the kidney function and coagulation function，and reduce serum inflammatory responses.