Abstract： Objective： To observe the clinical effect of Lishi Jiedu Zhiyang Decoction combined with Desonide Cream for eczema in children of damp-heat immersion type and analyze the influencing factors. Methods：A total of 154 cases of children with eczema of damp-heat immersion type were divided into the treatment group and the control group according to the random number table method， with 77 cases in each group. The control group was treated with Desonide Cream， and the treatment group was treated with Lishi Jiedu Zhiyang Decoction combined with Desonide Cream. The scores of itching degree and Eczema Area and Severity Index (EASI)，traditional Chinese medicine syndrome (TCM) scores，and levels of inflammatory factors in serum before and after treatment，as well as the clinical effects were compared between the two groups. After six- month follow- up， the recurrence were compared between the two groups， and the influencing factors of eczema recurrence in children were analyzed. Results： The total effective rate in the treatment group was higher than that in the control group (P＜0.05). After treatment， the itching degree scores ， EASI scores ， TCM syndrome scores ， and the levels of high-sensitivity C- reactive protein (hs- CRP)， interleukin 10 (IL- 10) and interleukin 4 (IL- 4) in serum in the two groups were lower than those before treatment (P＜0.05)， and the itching degree score， EASI score， TCM syndrome score，and levels of inflammatory factors in serum in the treatment group were lower than those in the control group (P＜0.05). After six-month follow-up，4 children lost contact and ultimately 133 cases were included. Among them，59 cases recurred (the recurrence group) and 74 cases did not recur (the nonrecurrence group). The results of univariate analysis showed that gender， disease duration， purchasing new furniture or decoration within six months of onset，having pets at home，and exposure to tobacco or dust in the living environment do not affect the recurrence of eczema (P＞0.05)； age， previous allergic history， treatment methods， use of materials such as paint in the bedroom， and levels of hs- CRP， IL-10，and IL-4 affect the recurrence of eczema (P＜0.05). The results of multivariate analysis showed that a history of allergies，treatment methods，use of materials such as paint in the bedroom，and IL-4 were independent influencing factors for the recurrence of eczema in children (P＜0.05)，the treatment method was a protective factor，and a history of allergies，use of materials such as paint in the bedroom，and IL-4 levels were risk factors. Conclusion： Lishi Jiedu Zhiyang Decoction combined with Desonide Cream is effective in treating eczema in children of damp- heat immersion type， which can effectively inhibit the inflammatory reactions and improve the symptoms. Previous allergies，use of materials such as paint in the bedroom， and IL- 4 levels are independent risk factors for eczema recurrence in children， and attention should be paid to protection.