Abstract： Objective： To observe the clinical effect of Compound Xueshuantong Capsules combined with Lucentis for retinal vein obstruction (RVO) complicated with macular edema and its effect on hemorheology. Methods：A total of 80 cases of patients with RVO complicated with macular edema were divided into the control group and the observation group according to the random number table method， with 40 cases in each group. The control group was treated with intravitreal injection with Lucentis，and the observation group was additionally treated with Compound Xueshuantong Capsules based on the treatment of the control group. Before and after treatment， traditional Chinese medicine (TCM) syndrome scores， thickness of macular fovea， Best Corrected Visual Acuity (BCVA)， and hemorheology indexes were compared between the two groups. The clinical effects and the occurrence of adverse reactions in the two groups were evaluated. Results：The total effective rate in the observation group was higher than that in the control group (P＜0.05). After treatment，TCM syndrome scores，thickness of macular fovea，fibrinogen， plasma viscosity， and red blood cell aggregation indexes in the two groups were decreased when compared with those before treatment (P＜0.05)， and BCVA was increased (P＜0.05)； TCM syndrome scores，thickness of macular fovea，and hemorheology indexes in the observation group were lower than those in the control group (P＜0.05)，and BCVA was higher than that in the control group (P＜0.05). There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups (P＞0.05). Conclusion：Compound Xueshuantong Capsules combined with Lucentis has a definite curative effect in the treatment of RVO complicated with macular edema，which can alleviate the symptoms of macular edema and improve hemorheology and visual acuity，with high safety.