Abstract： Objective： To observe the clinical effects， safety of Yiqi Huatan Tongluo Prescription combined with acupuncture for patients with cerebral infarction of qi deficiency and phlegm obstruction type in convalescence and its effect on ferritin levels in serum. Methods：A total of 114 patients with cerebral infarction of qi deficiency and phlegm obstruction type in convalescence were selected and randomly divided into two groups with 57 cases in each group. The control group received basic western medicine treatment and rehabilitation treatment，and the treatment group received Yiqi Huatan Tongluo Prescription combined with acupuncture. Both groups were treated for 21 days. The changes in scores of NIHSS， activities of daily living (ADL)， traditional Chinese medicine (TCM) syndrome scores， serum ferritin (SF) levels and adverse events in the two groups were compared between the two groups before and after treatment. Results：The total clinical effective rate was 77.36% in the treatment group，significantly higher than that of 54.55% in the control group，the difference being significant (P＜0.05)；the NIHSS scores in the two groups were decreased when compared with those before treatment，and the NIHSS score in the treatment group was lower than that in the control group，differences being significant (P＜0.05). The ADL scores in the two groups were increased when compared with those before treatment，and the ADL score in the treatment group was higher than that in the control group， differences being significant (P＜0.05). The TCM syndrome scores in the two groups were decreased when compared with those before treatment，and the TCM syndrome score in the treatment group was lower than that in the control group， differences being significant (P＜0.05). The levels of SF in the two groups were lower than those before treatment，and the SF level in the treatment group was lower than that in the control group，differences being significant (P＜0.05). During the treatment period， there were no significant abnormalities in blood routine，urine routine，liver and kidney function，and coagulation function in the two groups. Conclusion： The combination of Yiqi Huatan Tongluo Prescription and acupuncture can improve the degree of neurological impairment，activities of daily living and TCM syndromes，and reduce the SF levels of patients with cerebral infarction of qi deficiency and phlegm obstruction type in convalescence， without obvious adverse reactions.