Abstract： Objective： To observe the clinical effect of the therapy of point application combined with Nifedipine Sustained- Release Tablets on senile hypertension and its effect on the hemodynamics and hemorheology. Methods：A total of 87 senile patients with hypertension were selected and divided into the control group and the study group according to the random number table method，with 44 and 43 cases in each group. The control group was given treatment with Nifedipine Sustained- Release Tablets and the study group was additionally treated with point application based on the treatment of the control group. The clinical effects and levels of indexes of hemodynamics， including diastolic velocity (VD) and systolic velocity (VS) of basilar artery and pulsitility index (PI) of blood vessel， and indexes of hemorheology， including erythrocyte aggregation index， plasma viscosity， low shear viscosity and high shear viscosity were compared between the two groups. Results：The total effective rate was 95.35% in the study group and 79.55% in the control group，the difference being significant (P＜0.05). Before treatment，there was no significant difference being found in the comparisons of levels of VD， VS and PI (P＞0.05). After treatment， the levels of VD， VS and PI in the two groups were decreased when compared with those before treatment (P＜0.05)； the levels of VD， VS and PI were lower than that in the control group (P＜ 0.05). Before treatment， there was no significant difference being found in the comparisons of levels of erythrocyte aggregation index，plasma viscosity，low shear viscosity and high shear viscosity between the two groups (P＞0.05)；after treatment，the levels of above four indexes in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of above four indexes in the study group were lower than those in the control group (P＜0.05). Conclusion：The therapy of point application combined with Nifedipine Sustained- Release Tablets can significantly improve the clinical effect on senile hypertension and the state of hemodynamics and hemorheology of patients.