目的：观察栀子清肝汤加减方联合甲巯咪唑治疗甲状腺功能亢进症的临床疗效。方法：回顾性选 取2019 年1 月—2022 年6 月浙江中医药大学附属温岭中医院收治的甲状腺功能亢进症患者120 例，根据 治疗方法不同分为对照组与观察组各60 例。对照组给予甲巯咪唑片治疗，观察组给予栀子清肝汤加减方联合 甲巯咪唑治疗，2 组均治疗2 个月。比较2 组治疗前后中医证候积分、甲状腺功能指标、生活质量，并评估 2 组临床疗效及不良反应发生情况。结果：观察组总有效率为95.00%，高于对照组83.33%（P＜0.05）。治疗 2 个月后，观察组中医证候积分及血清游离三碘甲腺原氨酸（FT3） 和游离甲状腺素（FT4） 水平均较治疗前降 低（P＜0.05），促甲状腺激素（TSH） 水平与简明健康状况调查问卷（SF-36） 量表各维度评分及总分均升 高（P＜0.05）；观察组治疗后中医证候积分及血清FT3、FT4 水平均低于对照组（P＜0.05），简明健康状况调 查问卷（SF-36） 量表各维度评分及总分均高于对照组（P＜0.05），但2 组治疗后TSH 水平比较，差异无统计 学意义（P＞0.05）。2 组不良反应发生率比较，差异均无统计学意义（P＞0.05）。结论：栀子清肝汤加减方联 合甲巯咪唑治疗甲状腺功能亢进症疗效显著，能够改善患者甲状腺功能，提高生活质量，安全性较高。
Abstract： Objective： To observe the effect of modified Zhizi Qinggan Decoction combined with Methimazole for hyperthyroidism. Methods：A total of 120 cases of patients who had hyperthyroidism and admitted to Wenling Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University from January 2019 to June 2022 were retrospectively selected and divided into the control group and the observation group according to different treatment methods， with 60 cases in each group. The control group was treated with Methimazole Tablets， and the observation group was treated with modified Zhizi Qinggan Decoction and Methimazole. Both groups were treated for two months. Traditional Chinese medicine (TCM)syndrome scores， indicators of thyroid function， and quality of life were compared between the two groups before and after treatment. Clinical effects and the incidence of adverse reactions were evaluated. Results：The total effective rate was 95.00% in the observation group，higher than that of 83.33% in the control group (P＜0.05). After two months of treatment， TCM syndrome scores and the levels of free triiodothyronine (FT3) and free thyroxine (FT4) in serum in the observation group were decreased when compared with those before treatment (P＜0.05)， and the levels of thyroid stimulating hormone (TSH)， the scores of various dimensions and the total score of the Short Form Health Survey Questionnaire (SF- 36) were increased (P＜0.05)；TCM syndrome scores and the levels of FT3 and FT4 in serum in the observation group were lower than those in the control group (P＜0.05)， and the scores of various dimensions and total score of SF-36 in the observation group were higher than those in the control group (P＜0.05)；there was no significant difference being found in the comparison of TSH levels between the two groups (P＞0.05). There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups (P＞0.05). Conclusion： Modified Zhizi Qinggan Decoction combined with Methimazole has significant curative effects in the treatment of hyperthyroidism， and can improve thyroid function and quality of life with high safety.