目的：观察脑心通胶囊联合美托洛尔治疗冠心病心律失常的疗效及对炎性因子的影响。方法：按 随机数字表法将96 例冠心病心律失常患者分为对照组及治疗组各48 例。对照组给予美托洛尔治疗，治疗组应 用脑心通胶囊联合美托洛尔治疗。比较2 组治疗前后中医证候积分，24 h 动态心电图、炎性因子［超敏C－反 应蛋白（hs-CRP），单核细胞趋化蛋白1（MCP-1）、白细胞介素-6（IL-6）］水平的变化，观察2 组临床疗效 与不良反应发生情况。结果：治疗组总有效率为97.92%，对照组为81.25%，2 组比较，差异有统计学意 义（P＜0.05）。治疗后，2 组胸痛、胸闷、心悸、气短的中医证候积分均较治疗前下降（P＜0.05），治疗组上 述4 项中医证候积分均低于对照组（P＜0.05）。治疗后，2 组室性期前收缩数、短阵室速数均较治疗前降 低（P＜0.05），QTc 间期均较治疗前升高（P＜0.05）；治疗组室性期前收缩数、短阵室速数均低于对照 组（P＜0.05），QTc 间期大于对照组（P＜0.05）。治疗后，2 组MCP-1、hs-CRP、IL-6 水平均较治疗前下 降（P＜0.05），治疗组MCP-1、hs-CRP、IL-6 水平均低于对照组（P＜0.05）。2 组不良反应发生率比较，差 异无统计学意义（P＞0.05）。结论：脑心通胶囊联合美托洛尔治疗冠心病心律失常可获得较佳的临床疗效，可 改善患者临床症状及心电图指标，降低炎性因子水平，减少不良反应。
Abstract： Objective： To discuss the clinical effect of the therapy of Naoxintong Capsules combined with Metoprolol on arrhythmia of coronary heart disease and its effect on inflammatory factors. Methods：A total of 96 patients with arrythmia of coronary heart disease were divided into two groups according to the random number table method， with 48 cases in each group. The control group was given Metoprolol for treatment， and the treatment group was treated with Naoxintong Capsules combined with Metoprolol. Before and after treatment，the traditional Chinese medicine (TCM) syndrome scores，and levels of Holter and inflammatory factors were compared between the two groups； the clinical effects and incidence of adverse reactions were analyzed. Results：The total effective rate was 97.92% in the treatment group and 81.25% in the control group， the difference being significant (P＜0.05). After treatment， the TCM syndrome scores of chest pain，chest oppression，palpitation and shortness of breath in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above four scores in the treatment group were lower than those in the control group (P＜0.05). After treatment， the number of ventricular extrasystole and nonsustained ventricular tachycardia in both groups was respectively decreased when compared with those before treatment (P＜0.05)， and the QTc interphase was increased when compared with that before treatment (P＜0.05)； the number of ventricular extrasystole and nonsustained ventricular tachycardia in the treatment group was lower than that in the control group，respectively (P＜ 0.05)， and the QTc interphase was longer than that in the control group (P＜0.05). After treatment， the levels of MCP- 1， hs- CRP and IL- 6 in both groups were decreased when compared with those before treatment，and the above three levels in the treatment group were lower than those in the control group (P＜0.05). There was no significant difference being found in the comparison of incidence of adverse reactions between the two groups (P＞0.05). Conclusion：The therapy of Naoxintong Capsules combined with Metoprolol can achieve a good clinical effect on arrhythmia of coronary heart disease， which can improve the clinical symptoms and electrocardiogram indexes，decrease the levels of inflammatory factors and reduce the adverse reactions.