八味安神汤联合针刺内关、神门穴治疗室上性心动过速临床研究
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R541.71

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浙江省中医药管理局“十三五”重点计划项目(202100266)


Clinical Study on Bawei Anshen Decoction Combined with Acupuncture at Neiguan Point and Shenmen Point for Supraventricular Tachycardia
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    摘要:

    目的:观察八味安神汤联合针刺内关、神门穴治疗室上性心动过速的临床疗效。方法:选择82 例 室上性心动过速患者,按随机数字表法分为对照组和治疗组各41 例。对照组给予常规西医治疗,治疗组在对 照组基础上给予八味安神汤联合针刺内关、神门穴治疗。比较2 组治疗前后血管性血友病因子(vWF)、血浆 血栓素A2 (TXA2)、血清心肌肌钙蛋白(cTnI)、一氧化氮(NO)、肌酸激酶同工酶(CK-MB)、血浆内皮 素(ET)、氨基末端脑钠肽前体(NT-proBNP)、T 波峰末间期(Tpe)、校正QT 离散度(QTcd)、左心室射血 分数(LVEF)、心率水平及中医证候积分,并比较2 组临床疗效。结果:治疗组一次复律成功率高于对照 组(P<0.05),治疗组平均复律时间短于对照组(P<0.05)。治疗后,2 组Tpe、QTcd、心率水平均降低(P< 0.05),且治疗组低于对照组(P<0.05),2 组LVEF 水平均升高(P<0.05),且治疗组高于对照组(P< 0.05)。治疗后,2 组vWF、ET 水平均降低(P<0.05),且治疗组低于对照组(P<0.05),2 组NO 水平均升 高(P<0.05),且治疗组高于对照组(P<0.05)。治疗后,2 组cTnI、CK-MB、NT-proBNP、TXA2 水平均降 低(P<0.05),且治疗组低于对照组(P<0.05)。治疗后,2 组中医证候积分均降低(P<0.05),且治疗组低 于对照组(P<0.05)。治疗组总有效率95.12%,高于对照组80.49%(P<0.05)。结论:八味安神汤联合针刺 内关、神门穴治疗室上性心动过速患者,可终止室上性心动过速状态,加速复律,促进心肌复极,改善血管内 皮功能指标,降低cTnI、CK-MB、NT-proBNP、TXA2 水平,缓解临床症状,提升临床疗效。

    Abstract:

    Abstract:Objective:To observe clinical effect of Bawei Anshen Decoction combined with acupuncture at Neiguan point (PC6) and Shenmen point (TF4) for supraventricular tachycardia. Methods : A total of 82 cases of patients with supraventricular tachycardia were selected and divided into the reference group and the treatment group according to the random number table method,with 41 cases in each group. The reference group was given conventional western medicine treatment,and the trial group was additionally treated with Bawei Anshen Decoction combined with acupuncture at Neiguan point (PC6) and Shenmen point (TF4) based on the treatment of the reference group. The levels of von Willebrand factors (vWF), thromboxane A2 (TXA2) in plasma, cardiac troponin (cTnI) in serum, nitric oxide (NO), creatine kinase isoenzyme (CK-MB),endothelin (ET) in plasma,N-terminal pro-brain natriuretic peptide (NT-proBNP),T peak to end interval (Tpe), corrected QT dispersion (QTcd), left ventricular ejection fraction (LVEF), and heart rate, as well as traditional Chinese medicine (TCM) syndrome scores were compared between the two groups before and after treatment. Clinical effects were compared between the two groups. Results: The initial success rate of cardioversion in the treatment group was higher than that in the reference group (P<0.05),and the mean time of cardioversion in the treatment group was shorter than that in the reference group (P<0.05). After treatment, the levels of Tpe, QTcd, and heart rate in the two groups were decreased (P<0.05),and the levels of Tpe,QTcd,and heart rate in the treatment group were lower than those in the reference group (P<0.05); the levels of LVEF in the two groups were increased (P<0.05), and the LVEF level in the treatment group was higher than that in the reference group (P<0.05). After treatment,the levels of vWF and ET in the two groups were decreased (P<0.05),and the two levels in the treatment group were lower than those in the reference group (P<0.05);the levels of NO in the two groups were increased (P<0.05), and the NO level in the treatment group was higher than that in the reference group (P<0.05). After treatment,the levels of cTnI,CK- MB,NT- proBNP,and TXA2 in the two groups were decreased (P<0.05),and the four levels in the treatment group were lower than those in the reference group (P<0.05). After treatment,TCM syndrome scores in the two groups were decreased (P<0.05),and the scores in the treatment group were lower than those in the reference group (P<0.05). The total effective rate was 95.12% in the treatment group,higher than that of 80.49% in the reference group (P<0.05). Conclusion: For patients with supraventricular tachycardia, Bawei Anshen Decoction combined with acupuncture at Neiguan point (PC6) and Shenmen point (TF4) can terminate supraventricular tachycardia, accelerate cardioversion, promote myocardial repolarization, improve vascular endothelial function indicators, reduce the levels of cTnI, CK- MB, NT- proBNP, and TXA2, alleviate clinical symptoms,and enhance clinical effect.

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孙兵,廖骏,许海斌.八味安神汤联合针刺内关、神门穴治疗室上性心动过速临床研究[J].新中医,2023,55(21):34-39

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  • 在线发布日期: 2023-11-14
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